Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0264 | 1 | 1 |
Brugia malayi | Reprolysin | 0.0118 | 0.1912 | 0.1912 |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.0118 | 0.1904 | 0.1904 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.1904 | 0.2906 |
Brugia malayi | ADAMTS-like protease | 0.0118 | 0.1904 | 0.1904 |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.0202 | 0.655 | 0.655 |
Echinococcus multilocularis | adam | 0.0264 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.1904 | 0.2906 |
Brugia malayi | angiogenesis inhibito | 0.0118 | 0.1904 | 0.1904 |
Echinococcus multilocularis | subfamily M12B unassigned peptidase | 0.0202 | 0.655 | 0.655 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.655 | 1 |
Echinococcus granulosus | subfamily M12B unassigned peptidase | 0.0202 | 0.655 | 0.655 |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.0202 | 0.655 | 0.655 |
Echinococcus granulosus | adam | 0.0264 | 1 | 1 |
Loa Loa (eye worm) | reprolysin | 0.0202 | 0.655 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
BP (functional) | < 20 mmHg | Antihypertensive effect in spontaneously hypertensive rat (SHR), expressed as fall in blood pressure (BP) at 50 mg/kg dose given orally | ChEMBL. | 7452695 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.