Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0246 | 0.2076 | 0.8807 |
Onchocerca volvulus | 0.0058 | 0.0256 | 0.11 | |
Plasmodium falciparum | plasmepsin I | 0.0246 | 0.2076 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0085 | 0.0518 | 0.0518 |
Onchocerca volvulus | 0.0058 | 0.0256 | 0.11 | |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0256 | 0.11 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0058 | 0.0256 | 0.0256 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0058 | 0.0256 | 0.0256 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.0272 | 0.2322 | 1 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.1064 | 1 | 1 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.0272 | 0.2322 | 0.2322 |
Brugia malayi | aspartic protease BmAsp-1, identical | 0.0058 | 0.0256 | 0.11 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0246 | 0.2076 | 0.2076 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0246 | 0.2076 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0078 | 0.0449 | 0.0449 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0256 | 0.11 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0058 | 0.0256 | 0.0256 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0085 | 0.0518 | 0.0518 |
Schistosoma mansoni | sodium/solute symporter | 0.0272 | 0.2322 | 0.2322 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.2322 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0349 | 0.1501 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.1064 | 1 | 1 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0246 | 0.2076 | 0.8807 |
Brugia malayi | Pepsin A precursor | 0.0058 | 0.0256 | 0.11 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.1064 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.2322 | 1 |
Plasmodium falciparum | plasmepsin VI | 0.0246 | 0.2076 | 1 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.1064 | 1 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0058 | 0.0256 | 0.0256 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0246 | 0.2076 | 0.2076 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0058 | 0.0256 | 0.0256 |
Echinococcus multilocularis | solute carrier family 5 | 0.1064 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0078 | 0.0449 | 0.0449 |
Loa Loa (eye worm) | aspartyl protease 6 | 0.0058 | 0.0256 | 0.11 |
Schistosoma mansoni | high-affinity choline transporter | 0.0272 | 0.2322 | 0.2322 |
Brugia malayi | Eukaryotic aspartyl protease family protein | 0.0058 | 0.0256 | 0.11 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0058 | 0.0256 | 0.0256 |
Plasmodium vivax | plasmepsin IV, putative | 0.0246 | 0.2076 | 1 |
Brugia malayi | aspartic protease BmAsp-2, identical | 0.0058 | 0.0256 | 0.11 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0246 | 0.2076 | 1 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.0272 | 0.2322 | 0.2322 |
Brugia malayi | hypothetical protein | 0.0058 | 0.0256 | 0.11 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.2076 | 0.8938 |
Brugia malayi | GH02984p | 0.0272 | 0.2322 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0078 | 0.0449 | 0.1931 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0058 | 0.0256 | 0.0256 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0725 | 0.672 | 0.672 |
Brugia malayi | Sodium:solute symporter family protein | 0.0272 | 0.2322 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0725 | 0.672 | 0.672 |
Echinococcus granulosus | solute carrier family 5 | 0.1064 | 1 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0058 | 0.0256 | 0.0256 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0246 | 0.2076 | 0.8938 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0246 | 0.2076 | 0.2076 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.0272 | 0.2322 | 0.2322 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0058 | 0.0256 | 0.0256 |
Plasmodium falciparum | plasmepsin IV | 0.0246 | 0.2076 | 1 |
Brugia malayi | hypothetical protein | 0.0058 | 0.0256 | 0.11 |
Schistosoma mansoni | inositol transporter | 0.1064 | 1 | 1 |
Plasmodium falciparum | plasmepsin II | 0.0246 | 0.2076 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0078 | 0.0449 | 0.1931 |
Onchocerca volvulus | 0.0272 | 0.2322 | 1 | |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.0272 | 0.2322 | 0.2322 |
Schistosoma mansoni | inositol transporter | 0.1064 | 1 | 1 |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | 0.0058 | 0.0256 | 0.11 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 72 nM | Antiproliferative activity against human MDA-MB-231 cells after 4 days | ChEMBL. | 17533132 |
IC50 (functional) | = 72 nM | Antiproliferative activity against human MDA-MB-231 cells after 4 days | ChEMBL. | 17533132 |
IC50 (functional) | = 180 nM | Antiproliferative activity against human MCF7 cells after 5 days | ChEMBL. | 17533132 |
IC50 (functional) | = 180 nM | Antiproliferative activity against human MCF7 cells after 5 days | ChEMBL. | 17533132 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 17533132 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.