Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0562 | 0.1748 | 0.1748 |
Plasmodium falciparum | plasmepsin VI | 0.0562 | 0.1748 | 0.5 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0562 | 0.1748 | 0.269 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0562 | 0.1748 | 1 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0562 | 0.1748 | 1 |
Echinococcus granulosus | sodium:glucose cotransporter | 0.1233 | 0.6498 | 1 |
Onchocerca volvulus | 0.0315 | 0 | 0.5 | |
Echinococcus multilocularis | solute carrier family 5 | 0.1233 | 0.6498 | 1 |
Brugia malayi | Sodium:solute symporter family protein | 0.0315 | 0 | 0.5 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.1233 | 0.6498 | 1 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0562 | 0.1748 | 0.5 |
Schistosoma mansoni | inositol transporter | 0.1233 | 0.6498 | 0.6498 |
Plasmodium falciparum | plasmepsin II | 0.0562 | 0.1748 | 0.5 |
Brugia malayi | GH02984p | 0.0315 | 0 | 0.5 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.1728 | 1 | 1 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0562 | 0.1748 | 0.5 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0562 | 0.1748 | 1 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.1233 | 0.6498 | 1 |
Schistosoma mansoni | inositol transporter | 0.1233 | 0.6498 | 0.6498 |
Loa Loa (eye worm) | hypothetical protein | 0.0562 | 0.1748 | 1 |
Echinococcus granulosus | solute carrier family 5 | 0.1233 | 0.6498 | 1 |
Plasmodium falciparum | plasmepsin I | 0.0562 | 0.1748 | 0.5 |
Plasmodium falciparum | plasmepsin IV | 0.0562 | 0.1748 | 0.5 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.1233 | 0.6498 | 1 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0562 | 0.1748 | 0.269 |
Plasmodium vivax | plasmepsin IV, putative | 0.0562 | 0.1748 | 0.5 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.1233 | 0.6498 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.