Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | protein kinase Crk2 | 0.0045 | 1 | 1 |
Giardia lamblia | Xenotropic and polytropic murine leukemia virus receptor | 0.0005 | 0.0489 | 0.0489 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0045 | 1 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0045 | 1 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0045 | 1 | 1 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0045 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.5771 | 0.5771 |
Trypanosoma brucei | cyclin 2 | 0.0027 | 0.5771 | 0.5771 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0005 | 0.0489 | 0.0489 |
Giardia lamblia | Kinase, CMGC CDK | 0.0045 | 1 | 1 |
Trypanosoma brucei | CYC2-like cyclin, putative | 0.0027 | 0.5771 | 0.5771 |
Trypanosoma cruzi | Low-affinity phosphate transporter PHO91 | 0.0005 | 0.0489 | 0.0489 |
Echinococcus granulosus | cyclin dependent kinase | 0.0045 | 1 | 1 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0045 | 1 | 1 |
Toxoplasma gondii | SPX domain-containing protein | 0.0005 | 0.0489 | 0.0489 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0045 | 1 | 1 |
Toxoplasma gondii | vacuolar transporter chaperone VTC2 | 0.0005 | 0.0489 | 0.0489 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0045 | 1 | 1 |
Toxoplasma gondii | cyclin2 related protein | 0.0027 | 0.5771 | 0.5771 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0045 | 1 | 1 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0045 | 1 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0045 | 1 | 1 |
Trypanosoma cruzi | CYC2-like cyclin 4, putative | 0.0027 | 0.5771 | 0.5771 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0045 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0045 | 1 | 1 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0045 | 1 | 1 |
Plasmodium falciparum | protein kinase 5 | 0.0045 | 1 | 1 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0045 | 1 | 1 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0045 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0045 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0045 | 1 | 1 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0027 | 0.5771 | 0.5771 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0045 | 1 | 1 |
Leishmania major | CYC2-like cyclin, putative | 0.0027 | 0.5771 | 0.5771 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0045 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.9886 | 0.988 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0045 | 1 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0045 | 1 | 1 |
Echinococcus granulosus | xenotropic and polytropic retrovirus receptor 1 | 0.0005 | 0.0489 | 0.0489 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0045 | 1 | 1 |
Schistosoma mansoni | xenotropic and polytropic murine leukemia virus receptor xpr1 | 0.0005 | 0.0489 | 0.0489 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0045 | 1 | 1 |
Giardia lamblia | Kinase, CMGC CDK | 0.0045 | 1 | 1 |
Trypanosoma cruzi | CYC2-like cyclin 6, putative | 0.0027 | 0.5771 | 0.5771 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0045 | 1 | 1 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0045 | 1 | 1 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0045 | 1 | 1 |
Echinococcus multilocularis | xenotropic and polytropic retrovirus receptor 1 | 0.0005 | 0.0489 | 0.0489 |
Toxoplasma gondii | cyclin, N-terminal domain-containing protein | 0.0027 | 0.5771 | 0.5771 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0045 | 1 | 1 |
Leishmania major | sodium/sulphate symporter, putative | 0.0005 | 0.0489 | 0.0489 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.12 uM | Apoptosis inducing activity in human T47D cells by caspase activation assay | ChEMBL. | 17497765 |
EC50 (functional) | = 0.12 uM | Apoptosis inducing activity in human T47D cells by caspase activation assay | ChEMBL. | 17497765 |
EC50 (functional) | = 0.13 uM | Apoptosis inducing activity in human H1299 cells by caspase activation assay | ChEMBL. | 17497765 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 17497765 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.