Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | carbonic anhydrase-like protein | 0.4197 | 0.9217 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1766 | 0.3612 | 0.3871 |
Onchocerca volvulus | 0.02 | 0 | 0.5 | |
Onchocerca volvulus | Putative sulfate transporter | 0.02 | 0 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.3043 | 0.6556 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1766 | 0.3612 | 0.3871 |
Schistosoma mansoni | carbonic anhydrase | 0.1766 | 0.3612 | 0.3658 |
Echinococcus granulosus | geminin | 0.0364 | 0.038 | 0.0336 |
Echinococcus granulosus | carbonic anhydrase II | 0.4197 | 0.9217 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.1766 | 0.3612 | 0.3871 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.4197 | 0.9217 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1766 | 0.3612 | 0.3658 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.1766 | 0.3612 | 0.3871 |
Toxoplasma gondii | hypothetical protein | 0.1766 | 0.3612 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.1766 | 0.3612 | 0.3871 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.1897 | 0.3914 | 0.5926 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1766 | 0.3612 | 0.3871 |
Echinococcus multilocularis | geminin | 0.0364 | 0.038 | 0.0336 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1766 | 0.3612 | 0.3871 |
Trichomonas vaginalis | conserved hypothetical protein | 0.4537 | 1 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.1766 | 0.3612 | 0.3871 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.4197 | 0.9217 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.4537 | 1 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.4197 | 0.9217 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.4197 | 0.9217 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.3391 | 0.7358 | 0.7897 |
Echinococcus multilocularis | carbonic anhydrase | 0.1766 | 0.3612 | 0.3871 |
Echinococcus granulosus | carbonic anhydrase | 0.1766 | 0.3612 | 0.3871 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.4197 | 0.9217 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.4197 | 0.9217 | 0.5 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.3391 | 0.7358 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.4197 | 0.9217 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.1766 | 0.3612 | 0.3871 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1766 | 0.3612 | 0.3871 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.3391 | 0.7358 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1766 | 0.3612 | 0.3871 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.4197 | 0.9217 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1766 | 0.3612 | 0.3658 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1766 | 0.3612 | 0.3658 |
Echinococcus multilocularis | carbonic anhydrase II | 0.4197 | 0.9217 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1766 | 0.3612 | 0.3658 |
Loa Loa (eye worm) | hypothetical protein | 0.2345 | 0.4945 | 0.5329 |
Plasmodium falciparum | carbonic anhydrase | 0.1766 | 0.3612 | 0.5 |
Leishmania major | carbonic anhydrase family protein, putative | 0.3391 | 0.7358 | 0.7935 |
Echinococcus multilocularis | carbonic anhydrase | 0.1766 | 0.3612 | 0.3871 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.4197 | 0.9217 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.1724 | 0.3515 | 0.5311 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | 0 | Cytotoxicity in primary rat hepatocytes assessed as increase in LDH release after 24 hrs | ChEMBL. | 17804223 |
Activity (functional) | < 25 % | Cytotoxicity against human SW480 cells at 50 mM after 24 hrs | ChEMBL. | 17804223 |
Activity (functional) | < 25 % | Cytotoxicity against human SW480 cells at 50 mM after 24 hrs | ChEMBL. | 17804223 |
Activity (ADMET) | = 60 % | Cytotoxicity in primary rat hepatocytes assessed as decrease in number of hepatocytes after 24 hrs | ChEMBL. | 17804223 |
LD50 (functional) | = 142 mM | Cytotoxicity against human SW480 cells after 24 hrs | ChEMBL. | 17804223 |
LD50 (functional) | = 142 mM | Cytotoxicity against human SW480 cells after 24 hrs | ChEMBL. | 17804223 |
LogP | = 1.34 | Partition coefficient, log P of the compound | ChEMBL. | 17336073 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.