Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholecystokinin A receptor | Starlite/ChEMBL | References |
Homo sapiens | cholecystokinin B receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132882 | All targets in OG5_132882 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_132882 | All targets in OG5_132882 |
Brugia malayi | sulfakinin receptor protein | Get druggable targets OG5_132882 | All targets in OG5_132882 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | rhodopsin orphan GPCR | cholecystokinin A receptor | 428 aa | 373 aa | 19.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.1324 | 0.5 |
Brugia malayi | hypothetical protein | 0.0261 | 0.1324 | 0.5 |
Chlamydia trachomatis | phospho-N-acetylmuramoyl-pentapeptide-transferase | 0.0288 | 0.1794 | 0.5 |
Mycobacterium tuberculosis | Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX | 0.0758 | 1 | 1 |
Mycobacterium ulcerans | phospho-N-acetylmuramoyl-pentapeptide-transferase | 0.0758 | 1 | 1 |
Echinococcus granulosus | thymidine phosphorylase | 0.0657 | 0.8234 | 0.5 |
Echinococcus multilocularis | thymidine phosphorylase | 0.0657 | 0.8234 | 0.5 |
Mycobacterium tuberculosis | Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) | 0.0657 | 0.8234 | 0.8234 |
Treponema pallidum | phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) | 0.0288 | 0.1794 | 0.5 |
Mycobacterium ulcerans | thymidine phosphorylase | 0.0657 | 0.8234 | 0.8234 |
Wolbachia endosymbiont of Brugia malayi | phospho-N-acetylmuramoyl-pentapeptide-transferase | 0.0758 | 1 | 0.5 |
Brugia malayi | sulfakinin receptor protein | 0.0261 | 0.1324 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -9.11 | Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells | ChEMBL. | 17536796 |
Ki (binding) | = -5.6 | Displacement of [3H]L-364,718 from human recombinant CCK1 receptor expressed in CHOK1 cells | ChEMBL. | 17536796 |
Log Ki (binding) | = 5.6 | Displacement of [3H]L-364,718 from human recombinant CCK1 receptor expressed in CHOK1 cells | ChEMBL. | 17536796 |
Log Ki (binding) | = 9.11 | Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells | ChEMBL. | 17536796 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.