Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Anandamide amidohydrolase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.3 % |
Onchocerca volvulus | Anandamide amidohydrolase | 579 aa | 539 aa | 34.7 % | |
Schistosoma japonicum | Fatty-acid amide hydrolase 1, putative | Anandamide amidohydrolase | 579 aa | 499 aa | 24.6 % |
Echinococcus granulosus | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0286 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0286 | 1 | 1 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0249 | 0.7744 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0249 | 0.7744 | 1 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.0249 | 0.7744 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0249 | 0.7744 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0249 | 0.7744 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0249 | 0.7744 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0249 | 0.7744 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0249 | 0.7744 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0286 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0249 | 0.7744 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0249 | 0.7744 | 1 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.0249 | 0.7744 | 1 |
Echinococcus granulosus | inosine guanosine and xanthosine phosphorylase | 0.0198 | 0.4576 | 0.5909 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0249 | 0.7744 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0249 | 0.7744 | 1 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.0249 | 0.7744 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0286 | 1 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0198 | 0.4576 | 0.5909 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0286 | 1 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0249 | 0.7744 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0286 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0286 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0286 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0249 | 0.7744 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0286 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0286 | 1 | 1 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.0249 | 0.7744 | 1 |
Brugia malayi | purine nucleoside phosphorylase I, inosine and guanosine-specific family protein | 0.0249 | 0.7744 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0286 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.4576 | 1 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0249 | 0.7744 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0198 | 0.4576 | 0.5909 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0249 | 0.7744 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0249 | 0.7744 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.