Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.0256 | 0.1652 | 1 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.0295 | 0.2062 | 0.5 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA | 0.0752 | 0.6883 | 0.5 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0256 | 0.1652 | 1 |
Mycobacterium leprae | PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA | 0.0752 | 0.6883 | 1 |
Mycobacterium ulcerans | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1047 | 1 | 1 |
Brugia malayi | gamma-secretase subunit aph-1 | 0.0256 | 0.1652 | 1 |
Trypanosoma brucei | Aph-1 protein, putative | 0.01 | 0 | 0.5 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.01 | 0 | 0.5 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0256 | 0.1652 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.01 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1047 | 1 | 0.5 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.0256 | 0.1652 | 1 |
Treponema pallidum | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1047 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 0 % | Toxicity assessed as hemolysis in erythrocytes at 90 mg/L | ChEMBL. | 17542573 |
Activity (ADMET) | = 5 % | Toxicity assessed as hemolysis in erythrocytes at 180 mg/L | ChEMBL. | 17542573 |
MIC (functional) | = 0.125 mg/L | Antibacterial activity against Streptococcus pyogenes C203 after 24 hrs by broth microdilution method | ChEMBL. | 17542573 |
MIC (functional) | = 0.25 mg/L | Antibacterial activity against Staphylococcus aureus Smith after 24 hrs by broth microdilution method | ChEMBL. | 17542573 |
MIC (functional) | = 0.25 mg/L | Antibacterial activity against Enterococcus faecalis after 24 hrs by broth microdilution method | ChEMBL. | 17542573 |
MIC (functional) | = 0.25 mg/L | Antibacterial activity against vancomycin A-resistant Enterococcus faecalis after 24 hrs by broth microdilution method | ChEMBL. | 17542573 |
MIC (functional) | = 0.25 mg/L | Antibacterial activity against Enterococcus faecium after 24 hrs by broth microdilution method | ChEMBL. | 17542573 |
MIC (functional) | = 0.25 mg/L | Antibacterial activity against vancomycin A-resistant Enterococcus faecium clinical isolate after 24 hrs by broth microdilution method | ChEMBL. | 17542573 |
MIC (functional) | = 0.5 mg/L | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate after 24 hrs by broth microdilution method | ChEMBL. | 17542573 |
MIC (functional) | = 4 mg/L | Antibacterial activity against methicillin-resistant and vancomycin-intermediate resistant Staphylococcus aureus clinical isolate after 24 hrs by broth microdilution method | ChEMBL. | 17542573 |
MIC (functional) | = 4 mg/L | Antibacterial activity against vancomycin-intermediate resistant Staphylococcus aureus clinical isolate after 24 hrs by broth microdilution method | ChEMBL. | 17542573 |
MIC (functional) | > 32 mg/L | Antibacterial activity against Escherichia coli SKF12140 after 24 hrs by broth microdilution method | ChEMBL. | 17542573 |
MIC (functional) | > 32 mg/L | Antifungal activity against Candida albicans SKF2270 after 24 hrs by broth microdilution method | ChEMBL. | 17542573 |
MIC (functional) | > 32 mg/L | Antibacterial activity against Escherichia coli SKF12140 after 24 hrs by broth microdilution method | ChEMBL. | 17542573 |
MIC (functional) | > 32 mg/L | Antifungal activity against Candida albicans SKF2270 after 24 hrs by broth microdilution method | ChEMBL. | 17542573 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.