Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.1468 | 1 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1077 | 0.5989 | 0.5 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1141 | 0.665 | 0.5 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1141 | 0.665 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0974 | 0.4933 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1077 | 0.5989 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1077 | 0.5989 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1077 | 0.5989 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1077 | 0.5989 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.1077 | 0.5989 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1077 | 0.5989 | 0.5 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1141 | 0.665 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0648 | 0.1583 | 0.321 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1077 | 0.5989 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.1141 | 0.665 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1468 | 1 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1077 | 0.5989 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | > 40 % | Displacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane at 50 uM after 1 hr | ChEMBL. | 17539620 |
Activity (binding) | > 40 % | Displacement of [3H]YM 09151-2 from dopamine D2 receptor in lamb striatum membrane at 50 uM after 2 hrs | ChEMBL. | 17539620 |
Activity (binding) | > 40 % | Displacement of [3H]-R-PIA from adenosine A1 receptor in lamb striatum membrane at 50 uM after 1 hr | ChEMBL. | 17539620 |
Activity (binding) | > 40 % | Displacement of [3H]CGS 21680 from adenosine A2A receptor in lamb striatum membrane at 50 uM after 2 hrs | ChEMBL. | 17539620 |
Activity (binding) | > 40 % | Displacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane at 50 uM after 1 hr | ChEMBL. | 17539620 |
Activity (binding) | > 40 % | Displacement of [3H]YM 09151-2 from dopamine D2 receptor in lamb striatum membrane at 50 uM after 2 hrs | ChEMBL. | 17539620 |
Activity (binding) | > 40 % | Displacement of [3H]-R-PIA from adenosine A1 receptor in lamb striatum membrane at 50 uM after 1 hr | ChEMBL. | 17539620 |
Activity (binding) | > 40 % | Displacement of [3H]CGS 21680 from adenosine A2A receptor in lamb striatum membrane at 50 uM after 2 hrs | ChEMBL. | 17539620 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.