Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | ryanodine receptor | 0.094 | 0.2845 | 0.4912 |
Loa Loa (eye worm) | hypothetical protein | 0.0382 | 0.0315 | 0.0543 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0907 | 0.2697 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0806 | 0.224 | 0.2863 |
Echinococcus multilocularis | expressed protein | 0.0436 | 0.056 | 0.0715 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0907 | 0.2697 | 1 |
Brugia malayi | hypothetical protein | 0.0903 | 0.2679 | 0.2679 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0806 | 0.224 | 0.2863 |
Brugia malayi | cation channel family protein | 0.1075 | 0.3462 | 0.3462 |
Loa Loa (eye worm) | hypothetical protein | 0.0479 | 0.0752 | 0.1299 |
Schistosoma mansoni | ryanodine receptor related | 0.2515 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0617 | 0.1379 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0459 | 0.0663 | 0.1144 |
Echinococcus granulosus | expressed protein | 0.0436 | 0.056 | 0.0715 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0806 | 0.224 | 0.224 |
Schistosoma mansoni | hypothetical protein | 0.062 | 0.1396 | 0.1396 |
Echinococcus granulosus | ryanodine receptor 44f | 0.2037 | 0.7827 | 1 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.2037 | 0.7827 | 1 |
Loa Loa (eye worm) | ryanodine receptor | 0.0594 | 0.1275 | 0.22 |
Loa Loa (eye worm) | hypothetical protein | 0.1589 | 0.5792 | 1 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0769 | 0.2071 | 0.2071 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.1589 | 0.5792 | 0.7401 |
Echinococcus granulosus | ryanodine receptor 44f | 0.1589 | 0.5792 | 0.7401 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 22 nM | Antiproliferative activity against human Molt3 cells | ChEMBL. | 17197178 |
IC50 (functional) | = 22 nM | Antiproliferative activity against human Molt3 cells | ChEMBL. | 17197178 |
IC50 (functional) | = 122 nM | Cytotoxicity against human CEM cells | ChEMBL. | 17197178 |
IC50 (functional) | = 122 nM | Cytotoxicity against human CEM cells | ChEMBL. | 17197178 |
IC50 (functional) | = 193 nM | Antiproliferative activity against human DND1 cells | ChEMBL. | 17197178 |
IC50 (functional) | = 241 nM | Antiproliferative activity against human MCF7 cells | ChEMBL. | 17197178 |
IC50 (functional) | = 241 nM | Antiproliferative activity against human MCF7 cells | ChEMBL. | 17197178 |
IC50 (functional) | = 603 nM | Antiproliferative activity against human PC3 cells | ChEMBL. | 17197178 |
IC50 (functional) | = 603 nM | Antiproliferative activity against human PC3 cells | ChEMBL. | 17197178 |
IC50 (functional) | = 729 nM | Antiproliferative activity against human DU145 cells | ChEMBL. | 17197178 |
IC50 (functional) | = 729 nM | Antiproliferative activity against human DU145 cells | ChEMBL. | 17197178 |
IC50 (functional) | = 976 nM | Antiproliferative activity against human Bel-7402 cells | ChEMBL. | 17197178 |
IC50 (functional) | = 976 nM | Antiproliferative activity against human Bel-7402 cells | ChEMBL. | 17197178 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 17197178 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.