Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Matrilysin homolog | 0.0347 | 0.5596 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0084 | 0.0373 | 0.5 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0216 | 0.2999 | 0.2787 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0347 | 0.5596 | 1 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0123 | 0.1157 | 0.5 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0123 | 0.1157 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0378 | 0.6217 | 1 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0156 | 0.1813 | 0.2914 |
Schistosoma mansoni | dihydroceramide desaturase | 0.0168 | 0.2051 | 0.3371 |
Loa Loa (eye worm) | matrixin family protein | 0.0378 | 0.6217 | 1 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0216 | 0.2999 | 0.2787 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0165 | 0.1985 | 0.3245 |
Loa Loa (eye worm) | hypothetical protein | 0.0216 | 0.2999 | 0.4825 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0191 | 0.249 | 0.5 |
Brugia malayi | cation channel family protein | 0.0146 | 0.1613 | 0.2225 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.1813 | 0.2916 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.249 | 0.4005 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0569 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0222 | 0.3111 | 0.5406 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0112 | 0.0933 | 0.0657 |
Loa Loa (eye worm) | ryanodine receptor | 0.0081 | 0.0311 | 0.05 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0277 | 0.421 | 0.4034 |
Echinococcus granulosus | disintegrin and metalloproteinase | 0.0168 | 0.2051 | 0.1809 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.1813 | 0.2916 |
Brugia malayi | Hemopexin family protein | 0.0222 | 0.3111 | 0.4755 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.1813 | 0.2916 |
Loa Loa (eye worm) | ryanodine receptor | 0.0128 | 0.1246 | 0.2004 |
Brugia malayi | Ryanodine Receptor TM 4-6 family protein | 0.0342 | 0.5504 | 0.8796 |
Brugia malayi | Matrixin family protein | 0.0156 | 0.1813 | 0.2563 |
Loa Loa (eye worm) | disintegrin family protein | 0.0123 | 0.114 | 0.1834 |
Mycobacterium ulcerans | hydrolase | 0.0191 | 0.249 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0156 | 0.1813 | 0.2563 |
Loa Loa (eye worm) | matrixin family protein | 0.0347 | 0.5596 | 0.9001 |
Brugia malayi | Disintegrin family protein | 0.0168 | 0.2051 | 0.2965 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0191 | 0.249 | 0.3706 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0105 | 0.0785 | 0.0941 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0191 | 0.249 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0084 | 0.0383 | 0.0169 |
Schistosoma mansoni | ryanodine receptor related | 0.0342 | 0.5504 | 1 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0156 | 0.1813 | 0.2916 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0277 | 0.421 | 0.4034 |
Onchocerca volvulus | 0.0222 | 0.3111 | 0.3431 | |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0112 | 0.0933 | 0.0657 |
Brugia malayi | Matrixin family protein | 0.0156 | 0.1813 | 0.2563 |
Brugia malayi | Matrixin family protein | 0.0156 | 0.1813 | 0.2563 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0933 | 0.15 |
Echinococcus multilocularis | disintegrin and metalloproteinase | 0.0168 | 0.2051 | 0.1809 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Drug uptake (ADMET) | = 0.01 % ID/g | Biodistribution in brain of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 24 hrs | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 0.01 % ID/g | Biodistribution in brain of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 24 hrs | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 0.03 % ID/g | Biodistribution in blood of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 24 hrs | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 0.03 % ID/g | Biodistribution in blood of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 24 hrs | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 0.06 % ID/g | Biodistribution in brain of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 6 hrs | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 0.06 % ID/g | Biodistribution in brain of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 6 hrs | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 0.1 % ID/g | Biodistribution in brain of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 1 hr | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 0.1 % ID/g | Biodistribution in brain of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 1 hr | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 0.13 % ID/g | Biodistribution in heart of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 24 hrs | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 0.13 % ID/g | Biodistribution in heart of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 24 hrs | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 0.24 % ID/g | Biodistribution in blood of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 6 hrs | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 0.24 % ID/g | Biodistribution in blood of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 6 hrs | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 0.4 % ID/g | Biodistribution in lung of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 24 hrs | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 0.4 % ID/g | Biodistribution in lung of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 24 hrs | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 0.44 % ID/g | Biodistribution in heart of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 6 hrs | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 0.44 % ID/g | Biodistribution in heart of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 6 hrs | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 0.48 % ID/g | Biodistribution in blood of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 1 hr | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 0.48 % ID/g | Biodistribution in blood of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 1 hr | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 0.59 % ID/g | Biodistribution in kidney of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 24 hrs | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 0.59 % ID/g | Biodistribution in kidney of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 24 hrs | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 1.05 % ID/g | Biodistribution in heart of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 1 hr | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 1.05 % ID/g | Biodistribution in heart of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 1 hr | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 2.1 % ID/g | Biodistribution in lung of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 6 hrs | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 2.1 % ID/g | Biodistribution in lung of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 6 hrs | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 3.4 % ID/g | Biodistribution in melanoma of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 24 hrs | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 3.5 % ID/g | Biodistribution in melanoma of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 6 hrs | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 3.5 % ID/g | Biodistribution in liver of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 24 hrs | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 3.5 % ID/g | Biodistribution in liver of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 24 hrs | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 3.8 % ID/g | Biodistribution in melanoma of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 1 hr | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 4.9 % ID/g | Biodistribution in kidney of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 6 hrs | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 4.9 % ID/g | Biodistribution in kidney of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 6 hrs | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 6.9 % ID/g | Biodistribution in lung of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 1 hr | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 6.9 % ID/g | Biodistribution in lung of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 1 hr | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 15.2 % ID/g | Biodistribution in kidney of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 1 hr | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 15.2 % ID/g | Biodistribution in kidney of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 1 hr | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 27 % ID/g | Biodistribution in liver of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 6 hrs | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 27 % ID/g | Biodistribution in liver of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 6 hrs | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 43.2 % ID/g | Biodistribution in liver of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 1 hr | ChEMBL. | 17602544 |
Drug uptake (ADMET) | = 43.2 % ID/g | Biodistribution in liver of B16F0 tumor bearing C57BL/6J mouse at 0.37-0.74 MBq, iv after 1 hr | ChEMBL. | 17602544 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.