Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | ADAM-TS Spacer 1 family protein | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Schistosoma japonicum | ko:K08624 ADAM metallopeptidase with thrombospondin type 1 motif, 9, putative | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | peptide deformylase | 0.0479 | 1 | 0.5 |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.0109 | 0.17 | 1 |
Treponema pallidum | polypeptide deformylase (def) | 0.0479 | 1 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0183 | 0.3351 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0183 | 0.3351 | 0.5 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0046 | 0.0272 | 0.5 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0183 | 0.3351 | 0.5 |
Plasmodium falciparum | peptide deformylase | 0.0479 | 1 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0479 | 1 | 0.5 |
Onchocerca volvulus | Papilin homolog | 0.0035 | 0.0022 | 0.5 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0046 | 0.0272 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 0.0479 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0479 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0479 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0479 | 1 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0183 | 0.3351 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0183 | 0.3351 | 0.5 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0183 | 0.3351 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0183 | 0.3351 | 0.5 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0046 | 0.0272 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.17 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.