Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | peroxisome proliferator-activated receptor delta | Starlite/ChEMBL | References |
Homo sapiens | peroxisome proliferator-activated receptor gamma | Starlite/ChEMBL | References |
Homo sapiens | peroxisome proliferator-activated receptor alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K08701 nuclear receptor, subfamily 1, invertebrate, putative | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma japonicum | IPR008946,Nuclear receptor, ligand-binding,domain-containing | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | peroxisome proliferator-activated receptor delta | 441 aa | 369 aa | 24.7 % |
Echinococcus granulosus | ecdysone induced protein 78C | peroxisome proliferator-activated receptor gamma | 477 aa | 447 aa | 28.2 % |
Brugia malayi | ecdysteroid receptor | peroxisome proliferator-activated receptor alpha | 468 aa | 397 aa | 25.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0442 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0442 | 1 | 1 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0191 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0432 | 0.9609 | 0.9609 |
Schistosoma mansoni | glycogen phosphorylase | 0.0442 | 1 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.0442 | 1 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0442 | 1 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0442 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0191 | 0 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0442 | 1 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0442 | 1 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0442 | 1 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0442 | 1 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0442 | 1 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0442 | 1 | 0.5 |
Giardia lamblia | Glycogen phosphorylase | 0.0442 | 1 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0442 | 1 | 0.5 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0442 | 1 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0442 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 17 nM | Agonist activity at human PPARdelta receptor by cell based transactivation assay | ChEMBL. | 17524639 |
EC50 (functional) | = 17 nM | Agonist activity at human PPARdelta receptor by cell based transactivation assay | ChEMBL. | 17524639 |
EC50 (binding) | > 1 uM | Activity at human PPARgamma receptor by cell based transactivation assay | ChEMBL. | 17524639 |
EC50 (binding) | > 1 uM | Activity at human PPARalpha receptor by cell based transactivation assay | ChEMBL. | 17524639 |
EC50 (binding) | > 1 uM | Activity at human PPARgamma receptor by cell based transactivation assay | ChEMBL. | 17524639 |
EC50 (binding) | > 1 uM | Activity at human PPARalpha receptor by cell based transactivation assay | ChEMBL. | 17524639 |
Efficacy (binding) | = 79 % | Efficacy at human PPARdelta receptor by cell based transactivation assay | ChEMBL. | 17524639 |
Efficacy (binding) | = 79 % | Efficacy at human PPARdelta receptor by cell based transactivation assay | ChEMBL. | 17524639 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.