Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium voltage-gated channel, shaker-related subfamily, member 5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | voltage gated potassium channel | potassium voltage-gated channel, shaker-related subfamily, member 5 | 613 aa | 521 aa | 34.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glutamate receptor NMDA | 0.0351 | 0.8741 | 0.8429 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0188 | 0.2826 | 0.2632 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0165 | 0.1988 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0188 | 0.2826 | 0.2632 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0165 | 0.1988 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0273 | 0.5916 | 0.5916 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0165 | 0.1988 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0188 | 0.2826 | 0.2826 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0188 | 0.2826 | 0.2632 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0385 | 1 | 1 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0165 | 0.1988 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0186 | 0.2762 | 0.2567 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0188 | 0.2826 | 0.2826 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0188 | 0.2826 | 0.2826 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0165 | 0.1988 | 0.1988 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0186 | 0.2762 | 0.2762 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0163 | 0.1924 | 0.1707 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0188 | 0.2826 | 0.2632 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0188 | 0.2826 | 0.2826 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0188 | 0.2826 | 0.2826 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0385 | 1 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0273 | 0.5916 | 0.5806 |
Echinococcus granulosus | glutamate receptor 2 | 0.0188 | 0.2826 | 0.2632 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0163 | 0.1924 | 0.1924 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0117 | 0.0262 | 0.0262 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.29 uM | Inhibition of human Kv1.5 channel expressed in mouse L929 cells | ChEMBL. | 17462888 |
IC50 (binding) | = 0.29 uM | Inhibition of human Kv1.5 channel expressed in mouse L929 cells | ChEMBL. | 17462888 |
Inhibition (binding) | = 40 % | Inhibition of human ERG expressed in human embryonic kidney cells at 10 uM | ChEMBL. | 17462888 |
Inhibition (binding) | = 40 % | Inhibition of human ERG expressed in human embryonic kidney cells at 10 uM | ChEMBL. | 17462888 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.