Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Homo sapiens | cannabinoid receptor 1 (brain) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0279 | 0.0532 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.231 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0882 | 0.3343 | 1 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0279 | 0.0532 | 0.5 |
Mycobacterium tuberculosis | Probable amidase AmiD (acylamidase) (acylase) | 0.0279 | 0.0532 | 1 |
Mycobacterium ulcerans | amidase | 0.0279 | 0.0532 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.231 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0882 | 0.3343 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.0882 | 0.3343 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0882 | 0.3343 | 0.5 |
Mycobacterium tuberculosis | Probable amidase AmiB2 (aminohydrolase) | 0.0279 | 0.0532 | 1 |
Mycobacterium tuberculosis | Possible amidase (aminohydrolase) | 0.0279 | 0.0532 | 1 |
Mycobacterium ulcerans | peptide amidase, GatA | 0.0279 | 0.0532 | 1 |
Mycobacterium ulcerans | amidase | 0.0279 | 0.0532 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.231 | 1 | 1 |
Plasmodium falciparum | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0279 | 0.0532 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0882 | 0.3343 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.231 | 1 | 1 |
Mycobacterium tuberculosis | Probable amidase AmiA2 (aminohydrolase) | 0.0279 | 0.0532 | 1 |
Brugia malayi | Lipase family protein | 0.0882 | 0.3343 | 0.2969 |
Schistosoma mansoni | amidase | 0.231 | 1 | 1 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0279 | 0.0532 | 0.5 |
Mycobacterium tuberculosis | Probable amidase AmiC (aminohydrolase) | 0.0279 | 0.0532 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.231 | 1 | 1 |
Mycobacterium ulcerans | amidase | 0.0279 | 0.0532 | 1 |
Onchocerca volvulus | 0.0882 | 0.3343 | 0.5 | |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.231 | 1 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.0882 | 0.3343 | 1 |
Mycobacterium ulcerans | amidase | 0.0279 | 0.0532 | 1 |
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.0279 | 0.0532 | 0.5 |
Loa Loa (eye worm) | lipase | 0.0882 | 0.3343 | 0.2969 |
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.0279 | 0.0532 | 0.5 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0882 | 0.3343 | 0.2969 |
Mycobacterium ulcerans | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0279 | 0.0532 | 1 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0882 | 0.3343 | 0.2969 |
Mycobacterium ulcerans | amidase | 0.0279 | 0.0532 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0882 | 0.3343 | 0.5 |
Plasmodium vivax | glutamyl-tRNA(Gln) amidotransferase subunit A, putative | 0.0279 | 0.0532 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 10 uM | Displacement of [3H]CP55,940 from human CB2 receptor | ChEMBL. | 17604171 |
Ki (binding) | > 10 uM | Displacement of [3H]CP55,940 from human CB1 receptor | ChEMBL. | 17604171 |
Ki (binding) | = 10 uM | Displacement of [3H]CP55,940 from human CB2 receptor | ChEMBL. | 17604171 |
Ki (binding) | > 10 uM | Displacement of [3H]CP55,940 from human CB1 receptor | ChEMBL. | 17604171 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.