Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | amidase | 0.0226 | 0.0361 | 1 |
Mycobacterium tuberculosis | Probable amidase AmiD (acylamidase) (acylase) | 0.0226 | 0.0361 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.1878 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0764 | 0.35 | 1 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0226 | 0.0361 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0226 | 0.0361 | 0.5 |
Mycobacterium tuberculosis | Possible amidase (aminohydrolase) | 0.0226 | 0.0361 | 1 |
Mycobacterium ulcerans | amidase | 0.0226 | 0.0361 | 1 |
Mycobacterium ulcerans | peptide amidase, GatA | 0.0226 | 0.0361 | 1 |
Mycobacterium tuberculosis | Probable amidase AmiB2 (aminohydrolase) | 0.0226 | 0.0361 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0764 | 0.35 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0764 | 0.35 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.1878 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0764 | 0.35 | 1 |
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.0226 | 0.0361 | 0.5 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.1878 | 1 | 1 |
Mycobacterium ulcerans | amidase | 0.0226 | 0.0361 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.0764 | 0.35 | 1 |
Mycobacterium ulcerans | amidase | 0.0226 | 0.0361 | 1 |
Onchocerca volvulus | 0.0764 | 0.35 | 0.5 | |
Brugia malayi | Lipase family protein | 0.0764 | 0.35 | 0.3256 |
Mycobacterium tuberculosis | Probable amidase AmiA2 (aminohydrolase) | 0.0226 | 0.0361 | 1 |
Mycobacterium tuberculosis | Probable amidase AmiC (aminohydrolase) | 0.0226 | 0.0361 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.1878 | 1 | 1 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0226 | 0.0361 | 0.5 |
Schistosoma mansoni | amidase | 0.1878 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0764 | 0.35 | 1 |
Plasmodium falciparum | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0226 | 0.0361 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.1878 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1878 | 1 | 1 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0764 | 0.35 | 0.3256 |
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.0226 | 0.0361 | 0.5 |
Mycobacterium ulcerans | amidase | 0.0226 | 0.0361 | 1 |
Plasmodium vivax | glutamyl-tRNA(Gln) amidotransferase subunit A, putative | 0.0226 | 0.0361 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0764 | 0.35 | 0.5 |
Mycobacterium ulcerans | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0226 | 0.0361 | 1 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0764 | 0.35 | 0.3256 |
Loa Loa (eye worm) | lipase | 0.0764 | 0.35 | 0.3256 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 11.92 ug ml-1 | Antibacterial activity against Pseudomonas aeruginosa after 24 hrs by microbroth dilution technique | ChEMBL. | 17084947 |
MIC (functional) | = 15.35 ug ml-1 | Antibacterial activity against Klebsiella pneumoniae after 24 hrs by microbroth dilution technique | ChEMBL. | 17084947 |
MIC (functional) | = 16.65 ug ml-1 | Antibacterial activity against Escherichia coli after 24 hrs by microbroth dilution technique | ChEMBL. | 17084947 |
MIC (functional) | = 16.65 ug ml-1 | Antibacterial activity against Escherichia coli after 24 hrs by microbroth dilution technique | ChEMBL. | 17084947 |
MIC (functional) | = 25 ug ml-1 | Antifungal activity against Trichophyton tonsurans after 7 days | ChEMBL. | 17084947 |
MIC (functional) | = 25 ug ml-1 | Antifungal activity against Microsporum gypseum after 7 days | ChEMBL. | 17084947 |
MIC (functional) | = 25.65 ug ml-1 | Antibacterial activity against Staphylococcus aureus after 24 hrs by microbroth dilution technique | ChEMBL. | 17084947 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.