Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | amidase | 0.026 | 0.0499 | 1 |
Onchocerca volvulus | 0.0851 | 0.3456 | 0.5 | |
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.026 | 0.0499 | 0.5 |
Mycobacterium ulcerans | amidase | 0.026 | 0.0499 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.2158 | 1 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.0851 | 0.3456 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0851 | 0.3456 | 1 |
Plasmodium falciparum | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.026 | 0.0499 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.2158 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2158 | 1 | 1 |
Brugia malayi | Lipase family protein | 0.0851 | 0.3456 | 0.3113 |
Mycobacterium tuberculosis | Probable amidase AmiA2 (aminohydrolase) | 0.026 | 0.0499 | 1 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.026 | 0.0499 | 0.5 |
Mycobacterium tuberculosis | Probable amidase AmiC (aminohydrolase) | 0.026 | 0.0499 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.2158 | 1 | 1 |
Schistosoma mansoni | amidase | 0.2158 | 1 | 1 |
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.026 | 0.0499 | 0.5 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0851 | 0.3456 | 0.3113 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0851 | 0.3456 | 0.5 |
Mycobacterium ulcerans | amidase | 0.026 | 0.0499 | 1 |
Plasmodium vivax | glutamyl-tRNA(Gln) amidotransferase subunit A, putative | 0.026 | 0.0499 | 0.5 |
Mycobacterium ulcerans | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.026 | 0.0499 | 1 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0851 | 0.3456 | 0.3113 |
Loa Loa (eye worm) | lipase | 0.0851 | 0.3456 | 0.3113 |
Mycobacterium tuberculosis | Probable amidase AmiD (acylamidase) (acylase) | 0.026 | 0.0499 | 1 |
Mycobacterium ulcerans | amidase | 0.026 | 0.0499 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0851 | 0.3456 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.2158 | 1 | 1 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.026 | 0.0499 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.026 | 0.0499 | 0.5 |
Mycobacterium tuberculosis | Possible amidase (aminohydrolase) | 0.026 | 0.0499 | 1 |
Mycobacterium ulcerans | amidase | 0.026 | 0.0499 | 1 |
Mycobacterium ulcerans | peptide amidase, GatA | 0.026 | 0.0499 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.2158 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0851 | 0.3456 | 1 |
Mycobacterium tuberculosis | Probable amidase AmiB2 (aminohydrolase) | 0.026 | 0.0499 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0851 | 0.3456 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0851 | 0.3456 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antimicrobial activity against Mycobacterium tuberculosis H37Rv at 0.5 ug/ml after 6 weeks | ChEMBL. | 17112641 | |
Activity (functional) | Antimicrobial activity against Mycobacterium tuberculosis H37Rv at 10 ug/ml after 6 weeks | ChEMBL. | 17112641 | |
Activity (functional) | 0 | Antimicrobial activity against Mycobacterium tuberculosis H37Rv at 10 ug/ml after 6 weeks | ChEMBL. | 17112641 |
Activity (functional) | 0 | Antimicrobial activity against Mycobacterium smegmatis mc2 155 after 24 hrs at 0.5 ug/ml by broth dilution method | ChEMBL. | 17112641 |
Activity (functional) | 0 | Antimicrobial activity against Mycobacterium tuberculosis H37Rv at 0.5 ug/ml after 6 weeks | ChEMBL. | 17112641 |
MIC (functional) | = 4 ug ml-1 | Antimicrobial activity against Mycobacterium smegmatis str. MC2 155 after 24 hrs by broth dilution method | ChEMBL. | 17112641 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.