Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Possible amidase (aminohydrolase) | 0.0315 | 0.063 | 1 |
Mycobacterium ulcerans | amidase | 0.0315 | 0.063 | 1 |
Mycobacterium ulcerans | peptide amidase, GatA | 0.0315 | 0.063 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.087 | 0.2892 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.087 | 0.2892 | 1 |
Mycobacterium tuberculosis | Probable amidase AmiB2 (aminohydrolase) | 0.0315 | 0.063 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.2612 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.087 | 0.2892 | 1 |
Mycobacterium ulcerans | amidase | 0.0315 | 0.063 | 1 |
Mycobacterium tuberculosis | Probable amidase AmiD (acylamidase) (acylase) | 0.0315 | 0.063 | 1 |
Leishmania major | hypothetical protein, conserved | 0.087 | 0.2892 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.2612 | 1 | 1 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0315 | 0.063 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0315 | 0.063 | 0.5 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.087 | 0.2892 | 0.2414 |
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.0315 | 0.063 | 0.5 |
Plasmodium vivax | glutamyl-tRNA(Gln) amidotransferase subunit A, putative | 0.0315 | 0.063 | 0.5 |
Mycobacterium ulcerans | amidase | 0.0315 | 0.063 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.087 | 0.2892 | 0.5 |
Mycobacterium ulcerans | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0315 | 0.063 | 1 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.087 | 0.2892 | 0.2414 |
Loa Loa (eye worm) | lipase | 0.087 | 0.2892 | 0.2414 |
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.0315 | 0.063 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.087 | 0.2892 | 1 |
Mycobacterium ulcerans | amidase | 0.0315 | 0.063 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.2612 | 1 | 1 |
Mycobacterium ulcerans | amidase | 0.0315 | 0.063 | 1 |
Onchocerca volvulus | 0.087 | 0.2892 | 0.5 | |
Brugia malayi | Lipase family protein | 0.087 | 0.2892 | 0.2414 |
Mycobacterium tuberculosis | Probable amidase AmiA2 (aminohydrolase) | 0.0315 | 0.063 | 1 |
Mycobacterium tuberculosis | Probable amidase AmiC (aminohydrolase) | 0.0315 | 0.063 | 1 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0315 | 0.063 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.2612 | 1 | 1 |
Schistosoma mansoni | amidase | 0.2612 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.087 | 0.2892 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.2612 | 1 | 1 |
Plasmodium falciparum | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0315 | 0.063 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2612 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 10.5 uM | DPPH radical scavenging activity | ChEMBL. | 17602526 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.