Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | lipase | 0.0894 | 0.26 | 0.2056 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0894 | 0.26 | 0.2056 |
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.0358 | 0.0685 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0894 | 0.26 | 0.5 |
Plasmodium vivax | glutamyl-tRNA(Gln) amidotransferase subunit A, putative | 0.0358 | 0.0685 | 0.5 |
Mycobacterium ulcerans | amidase | 0.0358 | 0.0685 | 1 |
Mycobacterium ulcerans | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0358 | 0.0685 | 1 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0894 | 0.26 | 0.2056 |
Brugia malayi | Lipase family protein | 0.0894 | 0.26 | 0.2056 |
Mycobacterium tuberculosis | Probable amidase AmiA2 (aminohydrolase) | 0.0358 | 0.0685 | 1 |
Mycobacterium tuberculosis | Probable amidase AmiC (aminohydrolase) | 0.0358 | 0.0685 | 1 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0358 | 0.0685 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.2965 | 1 | 1 |
Schistosoma mansoni | amidase | 0.2965 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0894 | 0.26 | 1 |
Plasmodium falciparum | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0358 | 0.0685 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.2965 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2965 | 1 | 1 |
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.0358 | 0.0685 | 0.5 |
Mycobacterium ulcerans | amidase | 0.0358 | 0.0685 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.2965 | 1 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.0894 | 0.26 | 1 |
Mycobacterium ulcerans | amidase | 0.0358 | 0.0685 | 1 |
Onchocerca volvulus | 0.0894 | 0.26 | 0.5 | |
Trypanosoma brucei | lipase domain protein, putative | 0.0894 | 0.26 | 1 |
Mycobacterium tuberculosis | Probable amidase AmiB2 (aminohydrolase) | 0.0358 | 0.0685 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0894 | 0.26 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.2965 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0894 | 0.26 | 1 |
Mycobacterium tuberculosis | Possible amidase (aminohydrolase) | 0.0358 | 0.0685 | 1 |
Mycobacterium ulcerans | amidase | 0.0358 | 0.0685 | 1 |
Mycobacterium ulcerans | peptide amidase, GatA | 0.0358 | 0.0685 | 1 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0358 | 0.0685 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.2965 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0894 | 0.26 | 1 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0358 | 0.0685 | 0.5 |
Mycobacterium ulcerans | amidase | 0.0358 | 0.0685 | 1 |
Mycobacterium tuberculosis | Probable amidase AmiD (acylamidase) (acylase) | 0.0358 | 0.0685 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 62.5 ug ml-1 | Antibacterial activity against Aeromonas hydrophila by microbroth dilution method | ChEMBL. | 17125888 |
MIC (functional) | = 62.5 ug ml-1 | Antifungal activity against Candida albicans by microbroth dilution method | ChEMBL. | 17125888 |
MIC (functional) | = 62.5 ug ml-1 | Antifungal activity against Candida glabrata by broth dilution antifungal susceptibility testing | ChEMBL. | 17125888 |
MIC (functional) | = 62.5 ug ml-1 | Antifungal activity against Candida albicans by microbroth dilution method | ChEMBL. | 17125888 |
MIC (functional) | = 125 ug ml-1 | Antibacterial activity against Escherichia coli NRRL B3704 by microbroth dilution method | ChEMBL. | 17125888 |
MIC (functional) | = 125 ug ml-1 | Antibacterial activity against Salmonella typhimurium NRRL B4420 by microbroth dilution method | ChEMBL. | 17125888 |
MIC (functional) | = 125 ug ml-1 | Antibacterial activity against Escherichia coli NRRL B3704 by microbroth dilution method | ChEMBL. | 17125888 |
MIC (functional) | = 250 ug ml-1 | Antibacterial activity against Staphylococcus aureus NRRL B767 by microbroth dilution method | ChEMBL. | 17125888 |
MIC (functional) | = 250 ug ml-1 | Antibacterial activity against Bacillus cereus NRRL B3711 by microbroth dilution method | ChEMBL. | 17125888 |
MIC (functional) | = 250 ug ml-1 | Antibacterial activity against Streptococcus faecalis NRRL B14617 by microbroth dilution method | ChEMBL. | 17125888 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.