Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | lipase | 0.0575 | 0.3013 | 0.2832 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0575 | 0.3013 | 0.2832 |
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.0188 | 0.0252 | 0.5 |
Plasmodium vivax | glutamyl-tRNA(Gln) amidotransferase subunit A, putative | 0.0188 | 0.0252 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0575 | 0.3013 | 0.5 |
Mycobacterium ulcerans | amidase | 0.0188 | 0.0252 | 1 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0575 | 0.3013 | 0.2832 |
Mycobacterium ulcerans | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0188 | 0.0252 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0575 | 0.3013 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.1557 | 1 | 1 |
Plasmodium falciparum | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0188 | 0.0252 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1557 | 1 | 1 |
Brugia malayi | Lipase family protein | 0.0575 | 0.3013 | 0.2832 |
Mycobacterium tuberculosis | Probable amidase AmiA2 (aminohydrolase) | 0.0188 | 0.0252 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.1557 | 1 | 1 |
Mycobacterium tuberculosis | Probable amidase AmiC (aminohydrolase) | 0.0188 | 0.0252 | 1 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0188 | 0.0252 | 0.5 |
Schistosoma mansoni | amidase | 0.1557 | 1 | 1 |
Mycobacterium ulcerans | amidase | 0.0188 | 0.0252 | 1 |
Onchocerca volvulus | 0.0575 | 0.3013 | 0.5 | |
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.0188 | 0.0252 | 0.5 |
Mycobacterium ulcerans | amidase | 0.0188 | 0.0252 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.1557 | 1 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.0575 | 0.3013 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.1557 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0575 | 0.3013 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0575 | 0.3013 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0575 | 0.3013 | 1 |
Mycobacterium tuberculosis | Probable amidase AmiB2 (aminohydrolase) | 0.0188 | 0.0252 | 1 |
Mycobacterium tuberculosis | Possible amidase (aminohydrolase) | 0.0188 | 0.0252 | 1 |
Mycobacterium ulcerans | amidase | 0.0188 | 0.0252 | 1 |
Mycobacterium ulcerans | peptide amidase, GatA | 0.0188 | 0.0252 | 1 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0188 | 0.0252 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.1557 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0575 | 0.3013 | 1 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0188 | 0.0252 | 0.5 |
Mycobacterium tuberculosis | Probable amidase AmiD (acylamidase) (acylase) | 0.0188 | 0.0252 | 1 |
Mycobacterium ulcerans | amidase | 0.0188 | 0.0252 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | 0 | Inhibition of Leishmania donovani HOM/IN/80/DD8 in hamster at 50 mg/kg after 28 days | ChEMBL. | 17178176 |
Inhibition (functional) | = 46 % | Inhibition of Leishmania donovani HOM/IN/80/DD8 in hamster at 50 mg/kg ,ip after 7 days | ChEMBL. | 17178176 |
Inhibition (functional) | = 46 % | Inhibition of Leishmania donovani HOM/IN/80/DD8 in hamster at 50 mg/kg ,ip after 7 days | ChEMBL. | 17178176 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.