Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0712 | 0.3206 | 0.5 | |
Mycobacterium ulcerans | amidase | 0.0227 | 0.0385 | 1 |
Mycobacterium ulcerans | amidase | 0.0227 | 0.0385 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.1881 | 1 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.0712 | 0.3206 | 1 |
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.0227 | 0.0385 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1881 | 1 | 1 |
Plasmodium falciparum | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0227 | 0.0385 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.1881 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0712 | 0.3206 | 1 |
Schistosoma mansoni | amidase | 0.1881 | 1 | 1 |
Mycobacterium tuberculosis | Probable amidase AmiC (aminohydrolase) | 0.0227 | 0.0385 | 1 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0227 | 0.0385 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.1881 | 1 | 1 |
Mycobacterium tuberculosis | Probable amidase AmiA2 (aminohydrolase) | 0.0227 | 0.0385 | 1 |
Brugia malayi | Lipase family protein | 0.0712 | 0.3206 | 0.2934 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0712 | 0.3206 | 0.2934 |
Mycobacterium ulcerans | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0227 | 0.0385 | 1 |
Plasmodium vivax | glutamyl-tRNA(Gln) amidotransferase subunit A, putative | 0.0227 | 0.0385 | 0.5 |
Mycobacterium ulcerans | amidase | 0.0227 | 0.0385 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0712 | 0.3206 | 0.5 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0712 | 0.3206 | 0.2934 |
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.0227 | 0.0385 | 0.5 |
Loa Loa (eye worm) | lipase | 0.0712 | 0.3206 | 0.2934 |
Mycobacterium tuberculosis | Probable amidase AmiD (acylamidase) (acylase) | 0.0227 | 0.0385 | 1 |
Mycobacterium ulcerans | amidase | 0.0227 | 0.0385 | 1 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0227 | 0.0385 | 0.5 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0227 | 0.0385 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0712 | 0.3206 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.1881 | 1 | 1 |
Mycobacterium ulcerans | peptide amidase, GatA | 0.0227 | 0.0385 | 1 |
Mycobacterium ulcerans | amidase | 0.0227 | 0.0385 | 1 |
Mycobacterium tuberculosis | Possible amidase (aminohydrolase) | 0.0227 | 0.0385 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0712 | 0.3206 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.1881 | 1 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0712 | 0.3206 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0712 | 0.3206 | 1 |
Mycobacterium tuberculosis | Probable amidase AmiB2 (aminohydrolase) | 0.0227 | 0.0385 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Inhibition of Leishmania donovani HOM/IN/80/DD8 in hamster at 50 mg/kg ,ip after 7 days | ChEMBL. | 17178176 | |
Activity (functional) | 0 | Inhibition of Leishmania donovani HOM/IN/80/DD8 in hamster at 50 mg/kg ,ip after 7 days | ChEMBL. | 17178176 |
Inhibition (functional) | Inhibition of Leishmania donovani HOM/IN/80/DD8 in hamster at 50 mg/kg after 28 days | ChEMBL. | 17178176 | |
Inhibition (functional) | 0 | Inhibition of Leishmania donovani HOM/IN/80/DD8 in hamster at 50 mg/kg after 28 days | ChEMBL. | 17178176 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.