Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | 0.0764 | 0.3309 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.1977 | 1 | 1 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0238 | 0.0408 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0238 | 0.0408 | 0.5 |
Mycobacterium ulcerans | amidase | 0.0238 | 0.0408 | 1 |
Mycobacterium tuberculosis | Probable amidase AmiD (acylamidase) (acylase) | 0.0238 | 0.0408 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0764 | 0.3309 | 0.5 |
Mycobacterium tuberculosis | Probable amidase AmiB2 (aminohydrolase) | 0.0238 | 0.0408 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.0764 | 0.3309 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.1977 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0764 | 0.3309 | 1 |
Mycobacterium tuberculosis | Possible amidase (aminohydrolase) | 0.0238 | 0.0408 | 1 |
Mycobacterium ulcerans | peptide amidase, GatA | 0.0238 | 0.0408 | 1 |
Mycobacterium ulcerans | amidase | 0.0238 | 0.0408 | 1 |
Mycobacterium tuberculosis | Probable amidase AmiA2 (aminohydrolase) | 0.0238 | 0.0408 | 1 |
Brugia malayi | Lipase family protein | 0.0764 | 0.3309 | 0.3024 |
Schistosoma mansoni | amidase | 0.1977 | 1 | 1 |
Mycobacterium tuberculosis | Probable amidase AmiC (aminohydrolase) | 0.0238 | 0.0408 | 1 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0238 | 0.0408 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.1977 | 1 | 1 |
Plasmodium falciparum | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0238 | 0.0408 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.1977 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0764 | 0.3309 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1977 | 1 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.1977 | 1 | 1 |
Mycobacterium ulcerans | amidase | 0.0238 | 0.0408 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.0764 | 0.3309 | 1 |
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.0238 | 0.0408 | 0.5 |
Mycobacterium ulcerans | amidase | 0.0238 | 0.0408 | 1 |
Onchocerca volvulus | 0.0764 | 0.3309 | 0.5 | |
Loa Loa (eye worm) | lipase | 0.0764 | 0.3309 | 0.3024 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0764 | 0.3309 | 0.3024 |
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.0238 | 0.0408 | 0.5 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0764 | 0.3309 | 0.3024 |
Mycobacterium ulcerans | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0238 | 0.0408 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0764 | 0.3309 | 0.5 |
Plasmodium vivax | glutamyl-tRNA(Gln) amidotransferase subunit A, putative | 0.0238 | 0.0408 | 0.5 |
Mycobacterium ulcerans | amidase | 0.0238 | 0.0408 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 28 uM | Cytotoxicity against Huh 5-2 cells | ChEMBL. | 17084081 |
CC50 (ADMET) | > 33 uM | Cytotoxicity against MDBK cells | ChEMBL. | 17084081 |
EC50 (functional) | = 0.05 uM | Antiviral activity against BVDV in MDBK cells assessed as reduction of virus-induced cytopathic efect | ChEMBL. | 17084081 |
EC50 (functional) | = 18 uM | Antiviral activity against HCV in Huh 5-2 cells assessed as reduction of virus-induced cytopathic efect | ChEMBL. | 17084081 |
Ratio CC50/EC50 (functional) | = 2 | Selectivity index, ratio of CC50 for Huh 5-2 cells to EC50 for HCV | ChEMBL. | 17084081 |
Ratio CC50/EC50 (functional) | > 660 | Selectivity index, ratio of CC50 for MDBK cells to EC50 for BVDV | ChEMBL. | 17084081 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.