Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Neuronal acetylcholine receptor; alpha4/beta2 | Starlite/ChEMBL | References |
Homo sapiens | cholinergic receptor, nicotinic, alpha 4 (neuronal) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.0305 | 0.1073 | 0.5 |
Plasmodium falciparum | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0305 | 0.1073 | 0.5 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0305 | 0.1073 | 0.5 |
Brugia malayi | Lipase family protein | 0.0897 | 0.3447 | 0.3447 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.253 | 1 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0123 | 0.0343 | 0.0343 |
Mycobacterium tuberculosis | Probable amidase AmiA2 (aminohydrolase) | 0.0305 | 0.1073 | 1 |
Plasmodium vivax | glutamyl-tRNA(Gln) amidotransferase subunit A, putative | 0.0305 | 0.1073 | 0.5 |
Loa Loa (eye worm) | amidase | 0.0305 | 0.1073 | 0.1073 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0897 | 0.3447 | 0.5 |
Loa Loa (eye worm) | lipase | 0.0897 | 0.3447 | 0.3447 |
Mycobacterium ulcerans | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0305 | 0.1073 | 1 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0123 | 0.0343 | 0.0343 |
Onchocerca volvulus | 0.0897 | 0.3447 | 1 | |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0305 | 0.1073 | 0.1073 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0123 | 0.0343 | 0.0343 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.253 | 1 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0123 | 0.0343 | 0.0343 |
Mycobacterium ulcerans | amidase | 0.0305 | 0.1073 | 1 |
Mycobacterium tuberculosis | Probable amidase AmiD (acylamidase) (acylase) | 0.0305 | 0.1073 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0123 | 0.0343 | 0.0343 |
Mycobacterium ulcerans | amidase | 0.0305 | 0.1073 | 1 |
Mycobacterium tuberculosis | Probable amidase AmiC (aminohydrolase) | 0.0305 | 0.1073 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0343 | 0.0343 |
Mycobacterium tuberculosis | Probable amidase AmiB2 (aminohydrolase) | 0.0305 | 0.1073 | 1 |
Mycobacterium ulcerans | amidase | 0.0305 | 0.1073 | 1 |
Brugia malayi | putative amidase | 0.0305 | 0.1073 | 0.1073 |
Mycobacterium tuberculosis | Possible amidase (aminohydrolase) | 0.0305 | 0.1073 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.253 | 1 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.253 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0897 | 0.3447 | 1 |
Mycobacterium ulcerans | peptide amidase, GatA | 0.0305 | 0.1073 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.253 | 1 | 1 |
Schistosoma mansoni | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0305 | 0.1073 | 0.1073 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0897 | 0.3447 | 1 |
Schistosoma mansoni | amidase | 0.253 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0305 | 0.1073 | 0.5 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0123 | 0.0343 | 0.0343 |
Brugia malayi | Amidase family protein | 0.0305 | 0.1073 | 0.1073 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.253 | 1 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.0897 | 0.3447 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0305 | 0.1073 | 0.1073 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0897 | 0.3447 | 0.3447 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0305 | 0.1073 | 0.5 |
Echinococcus granulosus | glutamyl tRNAGln amidotransferase subunit A | 0.0305 | 0.1073 | 0.1073 |
Onchocerca volvulus | Putative nachr subunit | 0.0123 | 0.0343 | 0.0995 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0123 | 0.0343 | 0.0343 |
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.0305 | 0.1073 | 0.5 |
Loa Loa (eye worm) | amidase | 0.0305 | 0.1073 | 0.1073 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0897 | 0.3447 | 0.5 |
Echinococcus multilocularis | glutamyl tRNA(Gln) amidotransferase subunit A | 0.0305 | 0.1073 | 0.1073 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0123 | 0.0343 | 0.0343 |
Mycobacterium ulcerans | amidase | 0.0305 | 0.1073 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.0897 | 0.3447 | 1 |
Mycobacterium ulcerans | amidase | 0.0305 | 0.1073 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0897 | 0.3447 | 1 |
Brugia malayi | Amidase family protein | 0.0305 | 0.1073 | 0.1073 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0897 | 0.3447 | 0.3447 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0305 | 0.1073 | 0.1073 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = -6.26 | Agonist activity at alpha4beta2 in IMR-32cells assessed as calcium influx by FLIPR assay | ChEMBL. | 17585748 |
EC50 (functional) | = 16 nM | Agonist activity at rat striatal tissue assessed as dopamine release | ChEMBL. | 17585748 |
EC50 (functional) | = 0.55 uM | Agonist activity at alpha4beta2 in IMR-32cells assessed as calcium influx by FLIPR assay | ChEMBL. | 17585748 |
EC50 (functional) | = 0.55 uM | Agonist activity at alpha4beta2 in IMR-32cells assessed as calcium influx by FLIPR assay | ChEMBL. | 17585748 |
Ki (binding) | = -10.74 | Displacement of [3H]cytisine from alpha4beta2 in rat cerebral cortical membrane | ChEMBL. | 17585748 |
Ki (binding) | = 0.018 nM | Displacement of [3H]cytisine from alpha4beta2 in rat cerebral cortical membrane | ChEMBL. | 17585748 |
Ki (binding) | = 0.018 nM | Displacement of [3H]cytisine from alpha4beta2 in rat cerebral cortical membrane | ChEMBL. | 17585748 |
Log EC50 (functional) | = 6.26 | Agonist activity at alpha4beta2 in IMR-32cells assessed as calcium influx by FLIPR assay | ChEMBL. | 17585748 |
Log EC50 (functional) | = 7.79 | Agonist activity at rat striatal tissue assessed as dopamine release | ChEMBL. | 17585748 |
Log Ki (binding) | = 10.74 | Displacement of [3H]cytisine from alpha4beta2 in rat cerebral cortical membrane | ChEMBL. | 17585748 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.