Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0129 | 0.2666 | 0.3797 |
Brugia malayi | hypothetical protein | 0.0114 | 0.0332 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0114 | 0.0332 | 0.0332 |
Entamoeba histolytica | hypothetical protein | 0.0114 | 0.0332 | 0.5 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0178 | 1 | 0.5 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0178 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0114 | 0.0332 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0178 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0114 | 0.0332 | 0.5 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.0155 | 0.6479 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0114 | 0.0332 | 0.5 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0178 | 1 | 1 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.0155 | 0.6479 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0129 | 0.2666 | 0.2415 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kcat/Km (binding) | = 0.02 /M/s | Ratio of Kcat to Km in pimaricin thioesterase expressed in Escherichia coli | ChEMBL. | 17428661 |
Kcat/Km (binding) | = 3.6 /M/s | Ratio of Kcat to Km in 6-deoxyerythronolide B polyketide synthase thioesterase expressed in Escherichia coli | ChEMBL. | 17428661 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.