Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.1157 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.1157 | 1 |
Echinococcus granulosus | geminin | 0.0184 | 0.9929 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.9929 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0185 | 1 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0185 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.9929 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0185 | 1 | 0.5 |
Echinococcus multilocularis | geminin | 0.0184 | 0.9929 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0185 | 1 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0185 | 1 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0185 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1157 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0185 | 1 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.1157 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0185 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.