Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.4925 | 0.4432 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.292 | 0.0969 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.3873 | 0.3277 |
Echinococcus granulosus | mucolipin 3 | 0.0063 | 0.8858 | 0.8136 |
Schistosoma mansoni | mucolipin | 0.0063 | 0.8858 | 0.8747 |
Echinococcus granulosus | chromobox protein 1 | 0.0067 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.292 | 0.0969 |
Echinococcus multilocularis | chromobox protein 1 | 0.0067 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.4925 | 0.4925 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.3873 | 0.3277 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.292 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.3873 | 0.3277 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.3873 | 0.3873 |
Echinococcus multilocularis | chromobox protein 1 | 0.0067 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0067 | 1 | 1 |
Brugia malayi | Coelomocyte uptake defective protein 5 | 0.0063 | 0.8858 | 0.8747 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0886 | 0.0886 |
Brugia malayi | chromobox protein homolog 3 | 0.0038 | 0.216 | 0.1398 |
Trichomonas vaginalis | chromobox protein, putative | 0.0067 | 1 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0067 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.3873 | 0.3277 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0067 | 1 | 1 |
Schistosoma mansoni | chromobox protein | 0.0067 | 1 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0038 | 0.216 | 0.7399 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.4925 | 0.4432 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.4925 | 0.4925 |
Schistosoma mansoni | chromobox protein | 0.0067 | 1 | 1 |
Schistosoma mansoni | mucolipin | 0.0058 | 0.7462 | 0.7215 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.216 | 0.216 |
Loa Loa (eye worm) | mucolipin 1 | 0.0063 | 0.8858 | 0.8858 |
Echinococcus multilocularis | mucolipin 3 | 0.0063 | 0.8858 | 0.8136 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (ADMET) | = 14 % | Inhibition of CYP1A2 using CEC as substrate at 10 uM | ChEMBL. | 24900265 |
Inhibition (ADMET) | = 52 % | Inhibition of CYP3A4 using BFC as substrate at 10 uM | ChEMBL. | 24900265 |
Inhibition (binding) | = 55 % | Inhibition of CXCR2 in human polymorphonucleate cells assessed as inhibition of CXCL1-induced chemotaxis at 10'-8 M incubated for 15 mins prior to CXCL1-induction measured after 45 mins | ChEMBL. | 24900265 |
Inhibition (ADMET) | = 56 % | Inhibition of CYP2D6 using AMMC as substrate at 10 uM | ChEMBL. | 24900265 |
Inhibition (functional) | = 60 % | Inhibition of CXCL1-induced cell migration in human PMN cells at 0.01 uM by chemotaxis assay | ChEMBL. | 17665889 |
Inhibition (functional) | = 64 % | Inhibition of CXCL8-induced cell migration in human PMN cells at 0.01 uM by chemotaxis assay | ChEMBL. | 17665889 |
Inhibition (binding) | = 64 % | Inhibition of CXCR1/2 in human polymorphonucleate cells assessed as inhibition of CXCL8-induced chemotaxis at 10'-8 M incubated for 15 mins prior to CXCL8-induction measured after 45 mins | ChEMBL. | 24900265 |
Inhibition (ADMET) | = 73 % | Inhibition of CYP2C9 using 7MFC as substrate at 10 uM | ChEMBL. | 24900265 |
Inhibition (ADMET) | = 94 % | Inhibition of CYP2C19 using DBF as substrate at 10 uM | ChEMBL. | 24900265 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.