Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | epoxide hydrolase 2, cytoplasmic | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium ulcerans | epoxide hydrolase EphA | Get druggable targets OG5_129061 | All targets in OG5_129061 |
Mycobacterium tuberculosis | Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) | Get druggable targets OG5_129061 | All targets in OG5_129061 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0027 | 0.0064 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0027 | 0.0064 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0064 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0027 | 0.0064 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0027 | 0.0064 | 1 |
Toxoplasma gondii | beta-tubulin, putative | 0.0027 | 0.0064 | 1 |
Echinococcus multilocularis | tubulin subunit beta | 0.0027 | 0.0064 | 1 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0027 | 0.0064 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0064 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0027 | 0.0064 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0027 | 0.0064 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0064 | 1 |
Trypanosoma brucei | beta tubulin | 0.0027 | 0.0064 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0064 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0027 | 0.0064 | 1 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0027 | 0.0064 | 1 |
Giardia lamblia | Beta tubulin | 0.0027 | 0.0064 | 1 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0027 | 0.0064 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0027 | 0.0064 | 1 |
Loa Loa (eye worm) | beta-tubulin | 0.0027 | 0.0064 | 1 |
Giardia lamblia | Beta tubulin | 0.0027 | 0.0064 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0027 | 0.0064 | 1 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0027 | 0.0064 | 1 |
Mycobacterium tuberculosis | 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) | 0.2529 | 1 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0027 | 0.0064 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0064 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0027 | 0.0064 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0064 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0027 | 0.0064 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0064 | 1 |
Brugia malayi | Tubulin beta-1 chain | 0.0027 | 0.0064 | 1 |
Echinococcus multilocularis | beta tubulin | 0.0027 | 0.0064 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0027 | 0.0064 | 1 |
Loa Loa (eye worm) | tubulin beta chain | 0.0027 | 0.0064 | 1 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0027 | 0.0064 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0064 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0027 | 0.0064 | 1 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0027 | 0.0064 | 1 |
Trypanosoma brucei | beta tubulin | 0.0027 | 0.0064 | 1 |
Plasmodium falciparum | tubulin beta chain | 0.0027 | 0.0064 | 1 |
Echinococcus granulosus | tubulin subunit beta | 0.0027 | 0.0064 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0027 | 0.0064 | 1 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0027 | 0.0064 | 1 |
Trypanosoma brucei | beta tubulin | 0.0027 | 0.0064 | 1 |
Mycobacterium ulcerans | 3-dehydroquinate dehydratase | 0.2529 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0027 | 0.0064 | 1 |
Plasmodium vivax | tubulin beta chain, putative | 0.0027 | 0.0064 | 1 |
Brugia malayi | beta-tubulin, identical | 0.0027 | 0.0064 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0027 | 0.0064 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0064 | 1 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0027 | 0.0064 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0064 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0027 | 0.0064 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0027 | 0.0064 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0027 | 0.0064 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0064 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0064 | 1 |
Echinococcus granulosus | beta tubulin | 0.0027 | 0.0064 | 1 |
Toxoplasma gondii | beta tubulin | 0.0027 | 0.0064 | 1 |
Trichomonas vaginalis | tubulin, putative | 0.0027 | 0.0064 | 1 |
Trypanosoma cruzi | beta tubulin, putative | 0.0027 | 0.0064 | 1 |
Echinococcus granulosus | beta tubulin | 0.0027 | 0.0064 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0064 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0027 | 0.0064 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0027 | 0.0064 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0027 | 0.0064 | 1 |
Giardia lamblia | Beta tubulin | 0.0027 | 0.0064 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0027 | 0.0064 | 1 |
Echinococcus multilocularis | beta tubulin | 0.0027 | 0.0064 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0064 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0064 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0064 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0064 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0027 | 0.0064 | 1 |
Leishmania major | beta tubulin | 0.0027 | 0.0064 | 1 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0027 | 0.0064 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.1 nM | Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay | ChEMBL. | 17894481 |
IC50 (binding) | = 1.1 nM | Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay | ChEMBL. | 17894481 |
IC50 (binding) | = 1.1 nM | Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis | ChEMBL. | 22522007 |
IC50 (binding) | = 1.8 nM | Inhibition of human soluble epoxide hydrolase by fluorescence assay | ChEMBL. | 19216074 |
MIC (functional) | = 2.52 ug ml-1 | Antimycobacterial activity against Mycobacterium tuberculosis H37Ra | ChEMBL. | 22522007 |
Solubility | = 17 ug ml-1 | Solubility in sodium phosphate buffer at pH 7 | ChEMBL. | 17894481 |
Stabilty (ADMET) | = 9 % | Stability in human liver S9 fraction at 100 uM after 1 hr | ChEMBL. | 17894481 |
Stabilty (ADMET) | = 56 % | Stability in human liver microsomes at 100 uM after 1 hr | ChEMBL. | 17894481 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.