Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | plasminogen activator, urokinase | Starlite/ChEMBL | References |
Homo sapiens | elastase, neutrophil expressed | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | Mastin | plasminogen activator, urokinase | 414 aa | 340 aa | 24.4 % |
Echinococcus granulosus | transmembrane protease serine 3 | elastase, neutrophil expressed | 267 aa | 236 aa | 27.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Hexokinase family protein | 0.0647 | 1 | 1 |
Loa Loa (eye worm) | hexokinase type II | 0.0647 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.0647 | 1 | 0.5 |
Treponema pallidum | hexokinase (hxk) | 0.0647 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0406 | 0.4604 | 0.4604 |
Echinococcus multilocularis | hexokinase | 0.0647 | 1 | 0.5 |
Plasmodium falciparum | hexokinase | 0.0647 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0647 | 1 | 0.5 |
Schistosoma mansoni | hexokinase | 0.0647 | 1 | 0.5 |
Brugia malayi | hexokinase type II | 0.0206 | 0.0123 | 0.0123 |
Echinococcus granulosus | hexokinase | 0.0647 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0442 | 0.5396 | 0.5396 |
Leishmania major | hexokinase, putative | 0.0647 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0647 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0647 | 1 | 0.5 |
Onchocerca volvulus | 0.0647 | 1 | 1 | |
Trypanosoma brucei | hexokinase, putative | 0.0647 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.0647 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 2 | 0.0647 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0647 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.0647 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0647 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0647 | 1 | 0.5 |
Echinococcus granulosus | hexokinase type 2 | 0.0647 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0647 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0647 | 1 | 0.5 |
Onchocerca volvulus | 0.0647 | 1 | 1 | |
Loa Loa (eye worm) | hexokinase | 0.0647 | 1 | 1 |
Plasmodium vivax | hexokinase, putative | 0.0647 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0406 | 0.4604 | 0.4604 |
Echinococcus multilocularis | hexokinase type 2 | 0.0647 | 1 | 0.5 |
Toxoplasma gondii | hexokinase | 0.0647 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.0123 | 0.0123 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.0123 | 0.0123 |
Onchocerca volvulus | 0.0647 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2500 nM | Inhibition of human urokinase | ChEMBL. | 17850059 |
IC50 (binding) | = 2500 nM | Inhibition of human urokinase | ChEMBL. | 17850059 |
Ki (binding) | = 1600 nM | Inhibition of human NE | ChEMBL. | 17850059 |
Ki (binding) | = 1600 nM | Inhibition of human NE | ChEMBL. | 17850059 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.