Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0057 | 0.0021 | 0.0162 | |
Echinococcus granulosus | glutamate receptor 2 | 0.0627 | 0.0719 | 0.0701 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0627 | 0.0719 | 0.0701 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.0181 | 0.0196 |
Echinococcus granulosus | receptor type guanylyl cyclase | 0.0627 | 0.0719 | 0.0701 |
Loa Loa (eye worm) | hypothetical protein | 0.0627 | 0.0719 | 0.0719 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.0055 | 0.5 |
Echinococcus multilocularis | receptor type guanylyl cyclase | 0.0627 | 0.0719 | 0.0701 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.5582 | 0.6789 | 0.6783 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.0055 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1082 | 0.1276 | 0.1276 |
Trypanosoma cruzi | extracellular receptor, putative | 0.0627 | 0.0719 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.0017 | 0.0017 |
Echinococcus granulosus | tyrosine kinase | 0.0627 | 0.0719 | 0.0701 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.0055 | 0.5 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.3248 | 0.393 | 0.4843 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0085 | 0.0055 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.0017 | 0.0021 |
Entamoeba histolytica | hypothetical protein | 0.0627 | 0.0719 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0627 | 0.0719 | 0.0719 |
Echinococcus granulosus | glutamate receptor 2 | 0.0627 | 0.0719 | 0.0701 |
Loa Loa (eye worm) | glutamate receptor | 0.6664 | 0.8114 | 0.8114 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0627 | 0.0719 | 0.0719 |
Loa Loa (eye worm) | hypothetical protein | 0.0627 | 0.0719 | 0.0719 |
Loa Loa (eye worm) | hypothetical protein | 0.1708 | 0.2043 | 0.2043 |
Echinococcus multilocularis | tyrosine kinase | 0.0627 | 0.0719 | 0.0701 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0627 | 0.0719 | 0.0701 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0056 | 0.0019 | 0.5 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.0055 | 0.5 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.0055 | 0.5 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0085 | 0.0055 | 0.0036 |
Echinococcus granulosus | aryl hydrocarbon receptor | 0.0057 | 0.0021 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0627 | 0.0719 | 0.0719 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0627 | 0.0719 | 0.0701 |
Loa Loa (eye worm) | hypothetical protein | 0.0627 | 0.0719 | 0.0719 |
Echinococcus multilocularis | geminin | 0.0188 | 0.0181 | 0.0162 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.2719 | 0.3282 | 0.3269 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.8203 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0627 | 0.0719 | 0.0701 |
Leishmania major | extracellular receptor, putative | 0.0627 | 0.0719 | 0.5 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.6664 | 0.8114 | 1 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0627 | 0.0719 | 0.0701 |
Loa Loa (eye worm) | aryl Hydrocarbon receptor Associated protein family member | 0.0057 | 0.0021 | 0.0021 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0627 | 0.0719 | 0.0701 |
Brugia malayi | hypothetical protein | 0.0627 | 0.0719 | 0.0886 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0627 | 0.0719 | 0.0701 |
Loa Loa (eye worm) | metabotropic glutamate receptor 8 | 0.0627 | 0.0719 | 0.0719 |
Loa Loa (eye worm) | glutamate receptor | 0.2621 | 0.3162 | 0.3162 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0627 | 0.0719 | 0.0701 |
Loa Loa (eye worm) | hypothetical protein | 0.0411 | 0.0454 | 0.0454 |
Loa Loa (eye worm) | hypothetical protein | 0.0627 | 0.0719 | 0.0719 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0085 | 0.0055 | 0.0036 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0627 | 0.0719 | 0.0886 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.1708 | 0.2043 | 0.2519 |
Onchocerca volvulus | Huntingtin homolog | 0.0411 | 0.0454 | 0.3559 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0085 | 0.0055 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0627 | 0.0719 | 0.0701 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.0181 | 0.0196 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0056 | 0.0019 | 0.5 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0627 | 0.0719 | 0.0886 |
Loa Loa (eye worm) | hypothetical protein | 0.8203 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0021 | 0.0021 |
Brugia malayi | Guanylyl cyclase protein 23 | 0.0627 | 0.0719 | 0.0886 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.6037 | 0.7346 | 0.9054 |
Echinococcus granulosus | atrial natriuretic peptide receptor | 0.0627 | 0.0719 | 0.0701 |
Brugia malayi | hypothetical protein | 0.0057 | 0.0021 | 0.0026 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0627 | 0.0719 | 0.0701 |
Echinococcus granulosus | geminin | 0.0188 | 0.0181 | 0.0162 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0085 | 0.0055 | 0.5 |
Onchocerca volvulus | 0.0627 | 0.0719 | 0.5631 | |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.1082 | 0.1276 | 0.1573 |
Loa Loa (eye worm) | hypothetical protein | 0.0411 | 0.0454 | 0.0454 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0627 | 0.0719 | 0.0719 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.5582 | 0.6789 | 0.7353 |
Schistosoma mansoni | protein kinase | 0.0627 | 0.0719 | 0.0778 |
Brugia malayi | Probable ClpP-like protease | 0.0085 | 0.0055 | 0.0068 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.0055 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0627 | 0.0719 | 0.0778 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.1708 | 0.2043 | 0.2043 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0627 | 0.0719 | 0.0778 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0055 | 0.0055 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.1082 | 0.1276 | 1 |
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.1082 | 0.1276 | 0.1259 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0085 | 0.0055 | 0.0059 |
Onchocerca volvulus | Huntingtin homolog | 0.0411 | 0.0454 | 0.3559 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.1082 | 0.1276 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0017 | 0.0017 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0085 | 0.0055 | 0.5 |
Echinococcus multilocularis | atrial natriuretic peptide receptor | 0.0627 | 0.0719 | 0.0701 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.0017 | 0.0021 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.1708 | 0.2043 | 0.2043 |
Schistosoma mansoni | tyrosine kinase | 0.0627 | 0.0719 | 0.0778 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.0055 | 0.5 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.5582 | 0.6789 | 0.6783 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0627 | 0.0719 | 0.0701 |
Onchocerca volvulus | 0.0627 | 0.0719 | 0.5631 | |
Brugia malayi | hypothetical protein | 0.0411 | 0.0454 | 0.056 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0627 | 0.0719 | 0.0719 |
Echinococcus multilocularis | aryl hydrocarbon receptor | 0.0057 | 0.0021 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0627 | 0.0719 | 0.0719 |
Schistosoma mansoni | hypothetical protein | 0.1082 | 0.1276 | 0.1382 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.7577 | 0.9232 | 1 |
Echinococcus granulosus | GPCR family 3 C terminal | 0.1082 | 0.1276 | 0.1259 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.3248 | 0.393 | 0.4256 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0627 | 0.0719 | 0.0701 |
Onchocerca volvulus | Atrial natriuretic peptide receptor 3 homolog | 0.0627 | 0.0719 | 0.5631 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.