Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.1179 | 0 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.1179 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.6977 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.6977 | 1 | 1 |
Onchocerca volvulus | 0.1179 | 0 | 0.5 | |
Onchocerca volvulus | 0.1179 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.1897 | 0.1238 | 0.1238 |
Loa Loa (eye worm) | hypothetical protein | 0.6977 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.6977 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.1897 | 0.1238 | 0.1238 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.1179 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.6977 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.6977 | 1 | 1 |
Onchocerca volvulus | 0.1179 | 0 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.1179 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1897 | 0.1238 | 0.1238 |
Onchocerca volvulus | 0.1179 | 0 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.1179 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.6977 | 1 | 1 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.1897 | 0.1238 | 0.1238 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.1897 | 0.1238 | 0.1238 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.1897 | 0.1238 | 0.1238 |
Echinococcus granulosus | carboxylesterase 5A | 0.6977 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.6977 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.6977 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.1897 | 0.1238 | 0.1238 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.1179 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.6977 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.1179 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.6977 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 50 mm | Antimicrobial activity against Escherichia coli by agar diffusion technique | ChEMBL. | 17316908 |
IZ (functional) | = 50 mm | Antimicrobial activity against Escherichia coli by agar diffusion technique | ChEMBL. | 17316908 |
IZ (functional) | = 80 mm | Antifungal activity against Aspergilus niger by agar diffusion technique | ChEMBL. | 17316908 |
IZ (functional) | = 85 mm | Antimicrobial activity against Bacillus megaterium by agar diffusion technique | ChEMBL. | 17316908 |
IZ (functional) | = 86 mm | Antifungal activity against Aspergilus oryzae by agar diffusion technique | ChEMBL. | 17316908 |
IZ (functional) | = 87 mm | Antimicrobial activity against Bacillus subtilis by agar diffusion technique | ChEMBL. | 17316908 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.