Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 0.0436 | 0.0576 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 0.0436 | 0.0217 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0436 | 0.0943 |
Mycobacterium tuberculosis | Probable reductase | 0.0106 | 0.6877 | 0.8837 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.0436 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.3904 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0019 | 0.0436 | 0.0576 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0436 | 0.1763 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0436 | 0.1763 |
Brugia malayi | Carboxylesterase family protein | 0.0066 | 0.3904 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0066 | 0.3904 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0047 | 0.2471 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0118 | 0.7753 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0066 | 0.3904 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0436 | 0.1763 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.3904 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0436 | 0.1763 |
Echinococcus granulosus | dna polymerase eta | 0.0019 | 0.0436 | 0.0576 |
Schistosoma mansoni | DNA polymerase eta | 0.0019 | 0.0436 | 0.0217 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0106 | 0.6877 | 0.8837 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0016 | 0.0224 | 0.0906 |
Brugia malayi | Thioredoxin reductase | 0.0047 | 0.2471 | 0.6106 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0066 | 0.3904 | 0.3765 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0436 | 0.1763 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0016 | 0.0224 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0066 | 0.3904 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0436 | 0.1763 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0047 | 0.2471 | 0.6106 |
Leishmania major | DNA polymerase eta, putative | 0.0019 | 0.0436 | 0.0943 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0016 | 0.0224 | 0.0906 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0436 | 0.1763 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0436 | 0.0943 |
Brugia malayi | Carboxylesterase family protein | 0.0066 | 0.3904 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0019 | 0.0436 | 0.0943 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0436 | 0.0943 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0436 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0066 | 0.3904 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0436 | 0.0576 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0047 | 0.2471 | 0.5869 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0016 | 0.0224 | 0.5 |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 0.0436 | 0.0576 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0436 | 0.0576 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0106 | 0.6877 | 0.8837 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0436 | 0.1763 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0118 | 0.7753 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0047 | 0.2471 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0047 | 0.2471 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.0436 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0436 | 0.1763 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.0436 | 0.0281 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 0.0436 | 0.0217 |
Echinococcus granulosus | acetylcholinesterase | 0.0066 | 0.3904 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0047 | 0.2471 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0047 | 0.2471 | 0.6106 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0436 | 1 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0016 | 0.0224 | 0.0906 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0016 | 0.0224 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0047 | 0.2471 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0436 | 0.1763 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0436 | 0.1763 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0106 | 0.6877 | 0.8837 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0118 | 0.7753 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0066 | 0.3904 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0047 | 0.2471 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0436 | 0.0576 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0118 | 0.7753 | 1 |
Leishmania major | trypanothione reductase | 0.0047 | 0.2471 | 1 |
Brugia malayi | glutathione reductase | 0.0047 | 0.2471 | 0.6106 |
Leishmania major | DNA polymerase kappa, putative | 0.0019 | 0.0436 | 0.0943 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0.0436 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.0436 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0066 | 0.3904 | 1 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.0436 | 0.1763 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0106 | 0.6877 | 0.8837 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0019 | 0.0436 | 0.0943 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0047 | 0.2471 | 0.2985 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0016 | 0.0224 | 0.0906 |
Echinococcus multilocularis | acetylcholinesterase | 0.0066 | 0.3904 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0436 | 0.0943 |
Loa Loa (eye worm) | glutathione reductase | 0.0047 | 0.2471 | 0.5869 |
Treponema pallidum | NADH oxidase | 0.0016 | 0.0224 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0436 | 0.1763 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0436 | 0.1763 |
Plasmodium vivax | glutathione reductase, putative | 0.0047 | 0.2471 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0106 | 0.6877 | 0.8837 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0019 | 0.0436 | 0.1763 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0436 | 0.0576 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.0436 | 0.0281 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 12.5 ug ml-1 | Antifungal activity against Candida glabrata after 48 hrs by serial dilution method | ChEMBL. | 17337097 |
MIC (functional) | = 25 ug ml-1 | Antifungal activity against Candida albicans after 48 hrs by serial dilution method | ChEMBL. | 17337097 |
MIC (functional) | = 25 ug ml-1 | Antifungal activity against Candida krusei ATCC 6258 after 48 hrs by serial dilution method | ChEMBL. | 17337097 |
MIC (functional) | = 25 ug ml-1 | Antifungal activity against Candida albicans after 48 hrs by serial dilution method | ChEMBL. | 17337097 |
MIC (functional) | = 50 ug ml-1 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by serial dilution method | ChEMBL. | 17337097 |
MIC (functional) | = 50 ug ml-1 | Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by serial dilution method | ChEMBL. | 17337097 |
MIC (functional) | = 50 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 23556 after 24 hrs by serial dilution method | ChEMBL. | 17337097 |
MIC (functional) | = 50 ug ml-1 | Antibacterial activity against Pseudomonas aeruginosa ATCC 10145 after 24 hrs by serial dilution method | ChEMBL. | 17337097 |
MIC (functional) | = 50 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 23556 after 24 hrs by serial dilution method | ChEMBL. | 17337097 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.