Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.0174 | 0.399 | 0.1027 |
Trypanosoma cruzi | ferric reductase transmembrane protein, putative | 0.017 | 0.3872 | 0.5 |
Echinococcus multilocularis | sterol O acyltransferase 1 | 0.0231 | 0.5813 | 1 |
Echinococcus granulosus | sterol O acyltransferase 1 | 0.0231 | 0.5813 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0049 | 0 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.6462 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.5094 | 0.0948 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.6462 | 1 |
Leishmania major | ferric reductase, putative | 0.017 | 0.3872 | 0.5 |
Trypanosoma cruzi | ferric reductase transmembrane protein, putative | 0.017 | 0.3872 | 0.5 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0251 | 0.6462 | 0.3471 |
Treponema pallidum | hypothetical protein | 0.0049 | 0 | 0.5 |
Schistosoma mansoni | sterol O-acyltransferase 1 | 0.0231 | 0.5813 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0362 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.6462 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.6462 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.6462 | 1 |
Trypanosoma brucei | ferric reductase transmembrane protein, putative | 0.017 | 0.3872 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0362 | 1 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0224 | 0.5586 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0174 | 0.399 | 0.1027 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.5813 | 0.2274 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0251 | 0.6462 | 0.1603 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.6462 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.023 | 0.5786 | 0.2224 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1 uM | Inhibition of HCV NS3 protease by FRET assay | ChEMBL. | 17113777 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.