Detailed information for compound 436733

Basic information

Technical information
  • TDR Targets ID: 436733
  • Name: N-(4-amino-2-hydroxyphenyl)-4-fluorobenzamide
  • MW: 246.237 | Formula: C13H11FN2O2
  • H donors: 3 H acceptors: 2 LogP: 1.82 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)C(=O)Nc1ccc(cc1O)N
  • InChi: 1S/C13H11FN2O2/c14-9-3-1-8(2-4-9)13(18)16-11-6-5-10(15)7-12(11)17/h1-7,17H,15H2,(H,16,18)
  • InChiKey: IGXTXWLAHIFRKE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-amino-2-hydroxy-phenyl)-4-fluoro-benzamide
  • N-(4-azanyl-2-hydroxy-phenyl)-4-fluoro-benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0421 1 0.5
Echinococcus granulosus protoporphyrinogen oxidase 0.0366 0.8485 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0055 0 0.5
Echinococcus multilocularis protoporphyrinogen oxidase 0.0421 1 1
Loa Loa (eye worm) hypothetical protein 0.0055 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0055 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0055 0 0.5
Plasmodium vivax hypothetical protein, conserved 0.0055 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0055 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0055 0 0.5
Onchocerca volvulus 0.0055 0 0.5
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0055 0 0.5
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0055 0 0.5
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0322 0.7292 0.7292
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0055 0 0.5
Mycobacterium tuberculosis Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) 0.0366 0.8485 1
Plasmodium falciparum protoporphyrinogen oxidase 0.0055 0 0.5
Leishmania major UDP-galactopyranose mutase 0.0055 0 0.5
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0055 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0055 0 0.5
Toxoplasma gondii histone lysine-specific demethylase 0.0055 0 0.5
Brugia malayi amine oxidase, flavin-containing family protein 0.0055 0 0.5
Plasmodium vivax hypothetical protein, conserved 0.0055 0 0.5
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0421 1 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0055 0 0.5
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0055 0 0.5
Brugia malayi SWIRM domain containing protein 0.0055 0 0.5
Brugia malayi hypothetical protein 0.0055 0 0.5
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0421 1 1

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 15.6 ug ml-1 Antibacterial activity against Escherichia coli ATCC 25922 assessed after 24 hrs by serial dilution method ChEMBL. 17223562
MIC (functional) = 15.6 ug ml-1 Antibacterial activity against Escherichia coli ATCC 25922 assessed after 24 hrs by serial dilution method ChEMBL. 17223562
MIC (functional) = 62.5 ug ml-1 Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed after 24 hrs by serial dilution method ChEMBL. 17223562
MIC (functional) = 125 ug ml-1 Antibacterial activity against Bacillus subtilis isolate assessed after 24 hrs by serial dilution method ChEMBL. 17223562
MIC (functional) = 125 ug ml-1 Antibacterial activity against Staphylococcus aureus isolate assessed after 24 hrs by serial dilution method ChEMBL. 17223562
MIC (functional) = 125 ug ml-1 Antibacterial activity against Pseudomonas aeruginosa ATCC 25853 assessed after 24 hrs by serial dilution method ChEMBL. 17223562
MIC (functional) = 125 ug ml-1 Antibacterial activity against Bacillus subtilis ATCC 6633 assessed after 24 hrs by serial dilution method ChEMBL. 17223562
MIC (functional) = 125 ug ml-1 Antifungal activity against Candida albicans ATCC 10231 assessed after 48 hrs by serial dilution method ChEMBL. 17223562
MIC (functional) = 125 ug ml-1 Antifungal activity against Candida albicans isolate assessed after 48 hrs by serial dilution method ChEMBL. 17223562
MIC (functional) = 125 ug ml-1 Antifungal activity against Candida albicans ATCC 10231 assessed after 48 hrs by serial dilution method ChEMBL. 17223562
MIC (functional) = 125 ug ml-1 Antifungal activity against Candida albicans isolate assessed after 48 hrs by serial dilution method ChEMBL. 17223562
MIC (functional) = 250 ug ml-1 Antibacterial activity against Klebsiella pneumoniae isolate assessed after 24 hrs by serial dilution method ChEMBL. 17223562
MIC (functional) = 250 ug ml-1 Antibacterial activity against Pseudomonas aeruginosa isolate assessed after 24 hrs by serial dilution method ChEMBL. 17223562
MIC (functional) = 250 ug ml-1 Antibacterial activity against Escherichia coli isolate assessed after 24 hrs by by serial dilution method ChEMBL. 17223562
MIC (functional) = 250 ug ml-1 Antibacterial activity against Klebsiella pneumoniae RSHM 574 assessed after 24 hrs by serial dilution method ChEMBL. 17223562
MIC (functional) = 250 ug ml-1 Antibacterial activity against Escherichia coli isolate assessed after 24 hrs by by serial dilution method ChEMBL. 17223562

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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