Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0411 | 1 | 1 | |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0041 | 0.0512 | 0.5 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0411 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0085 | 0.1632 | 0.1632 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.1632 | 0.1632 |
Echinococcus multilocularis | peroxidasin | 0.0085 | 0.1632 | 0.5356 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.1632 | 0.1632 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0085 | 0.1632 | 0.1632 |
Loa Loa (eye worm) | tyrosinase 1 | 0.0411 | 1 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0127 | 0.2711 | 0.9198 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0041 | 0.0512 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.1632 | 0.1632 |
Loa Loa (eye worm) | acetyltransferase | 0.014 | 0.3048 | 0.3048 |
Echinococcus granulosus | peroxidasin | 0.0085 | 0.1632 | 0.5539 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.1632 | 0.1632 |
Schistosoma mansoni | tyrosinase precursor | 0.0411 | 1 | 1 |
Onchocerca volvulus | 0.0085 | 0.1632 | 0.1632 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0085 | 0.1632 | 0.1632 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0041 | 0.0512 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0085 | 0.1632 | 0.1632 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0136 | 0.2947 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0127 | 0.2711 | 0.2711 |
Onchocerca volvulus | Peroxidase homolog | 0.0085 | 0.1632 | 0.1632 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.1632 | 0.1632 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0085 | 0.1632 | 0.1632 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.1632 | 0.1632 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0038 | 0.0424 | 0.5 |
Brugia malayi | hypothetical protein | 0.0085 | 0.1632 | 0.1632 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0085 | 0.1632 | 0.1632 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0041 | 0.0512 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0085 | 0.1632 | 0.1632 |
Loa Loa (eye worm) | hypothetical protein | 0.0411 | 1 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0411 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.1632 | 0.1632 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0085 | 0.1632 | 0.1632 |
Schistosoma mansoni | tyrosinase precursor | 0.0411 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0085 | 0.1632 | 0.1632 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0411 | 1 | 1 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0411 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.1632 | 0.1632 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0038 | 0.0424 | 1 |
Onchocerca volvulus | 0.0411 | 1 | 1 | |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0411 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0085 | 0.1632 | 0.1632 |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0411 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0085 | 0.1632 | 0.1632 |
Onchocerca volvulus | Peroxidasin homolog | 0.0085 | 0.1632 | 0.1632 |
Onchocerca volvulus | 0.0085 | 0.1632 | 0.1632 | |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0411 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.1632 | 0.1632 |
Onchocerca volvulus | 0.0085 | 0.1632 | 0.1632 | |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0041 | 0.0512 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.1632 | 0.1632 |
Onchocerca volvulus | Peroxidasin homolog | 0.0085 | 0.1632 | 0.1632 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.1632 | 0.1632 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0127 | 0.2711 | 0.8894 |
Onchocerca volvulus | 0.0411 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.1632 | 0.1632 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.014 | 0.3048 | 1 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0038 | 0.0424 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0085 | 0.1632 | 0.1632 |
Schistosoma mansoni | peroxidasin | 0.0085 | 0.1632 | 0.1632 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.1632 | 0.1632 |
Loa Loa (eye worm) | hypothetical protein | 0.0411 | 1 | 1 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.014 | 0.3048 | 0.3048 |
Brugia malayi | Animal haem peroxidase family protein | 0.0085 | 0.1632 | 0.1632 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.014 | 0.3048 | 0.3048 |
Onchocerca volvulus | 0.0411 | 1 | 1 | |
Schistosoma mansoni | lipoxygenase | 0.0089 | 0.1731 | 0.1731 |
Brugia malayi | Animal haem peroxidase family protein | 0.0085 | 0.1632 | 0.1632 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.1632 | 0.1632 |
Schistosoma mansoni | peroxidasin | 0.0085 | 0.1632 | 0.1632 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0041 | 0.0512 | 0.1738 |
Brugia malayi | Blistered cuticle protein 3 | 0.0085 | 0.1632 | 0.1632 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibition of human factor 10a | ChEMBL. | 17416533 |
IC50 (binding) | > 100 uM | Inhibition of human factor 10a | ChEMBL. | 17416533 |
Selectivity ratio (binding) | > 100 | Selectivity for human factor 10a over human trypsin | ChEMBL. | 17416533 |
Selectivity ratio (binding) | > 7000 | Selectivity for human factor 10a over human thrombin | ChEMBL. | 17416533 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.