Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | heat shock protein 90, putative | 0.0556 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0451 | 0.6693 | 0.6002 |
Trypanosoma brucei | heat shock protein, putative | 0.0556 | 1 | 1 |
Echinococcus granulosus | heat shock protein 90 | 0.0451 | 0.6693 | 0.6002 |
Plasmodium falciparum | heat shock protein 90, putative | 0.0286 | 0.1476 | 0.1256 |
Giardia lamblia | Grp94/Hsp90 | 0.0459 | 0.6946 | 0.0763 |
Echinococcus multilocularis | heat shock protein | 0.0556 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | heat shock protein 90 | 0.0459 | 0.6946 | 0.5 |
Echinococcus multilocularis | endoplasmin | 0.0459 | 0.6946 | 0.6308 |
Schistosoma mansoni | heat shock protein | 0.0556 | 1 | 1 |
Mycobacterium ulcerans | heat shock protein 90 | 0.0459 | 0.6946 | 0.5 |
Plasmodium vivax | heat shock protein 90, putative | 0.0294 | 0.1729 | 0.1514 |
Leishmania major | heat shock protein 83-1 | 0.0556 | 1 | 1 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0556 | 1 | 1 |
Leishmania major | lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative | 0.0459 | 0.6946 | 0.6308 |
Leishmania major | heat shock protein 83-1 | 0.0556 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0556 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0556 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0556 | 1 | 1 |
Brugia malayi | heat shock protein 90 | 0.0556 | 1 | 1 |
Plasmodium falciparum | endoplasmin, putative | 0.0344 | 0.3307 | 0.3133 |
Leishmania major | heat shock protein 83-1 | 0.0556 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0556 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0556 | 1 | 1 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0556 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0556 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0556 | 1 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0344 | 0.3307 | 0.3307 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0556 | 1 | 1 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0556 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0556 | 1 | 1 |
Echinococcus granulosus | heat shock protein 90 | 0.0556 | 1 | 1 |
Toxoplasma gondii | heat shock protein 90, putative | 0.0556 | 1 | 1 |
Loa Loa (eye worm) | heat shock protein 90 | 0.0556 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0556 | 1 | 1 |
Mycobacterium leprae | PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) | 0.0459 | 0.6946 | 0.5 |
Plasmodium vivax | heat shock protein 86, putative | 0.0556 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0556 | 1 | 1 |
Trichomonas vaginalis | endoplasmin, putative | 0.0344 | 0.3307 | 0.3307 |
Trichomonas vaginalis | heat shock protein, putative | 0.0451 | 0.6693 | 0.6693 |
Trichomonas vaginalis | heat shock protein, putative | 0.0459 | 0.6946 | 0.6946 |
Trypanosoma brucei | heat shock protein, putative | 0.0556 | 1 | 1 |
Echinococcus granulosus | heat shock protein | 0.0556 | 1 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0459 | 0.6946 | 0.6946 |
Trichomonas vaginalis | heat shock protein, putative | 0.0556 | 1 | 1 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0556 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0317 | 0.2464 | 0.0889 |
Leishmania major | heat shock protein 83-1 | 0.0556 | 1 | 1 |
Loa Loa (eye worm) | endoplasmin | 0.0556 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0556 | 1 | 1 |
Mycobacterium tuberculosis | Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) | 0.0459 | 0.6946 | 0.5 |
Plasmodium vivax | endoplasmin, putative | 0.0556 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0556 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0451 | 0.6693 | 0.6002 |
Echinococcus multilocularis | heat shock protein 90 | 0.0451 | 0.6693 | 0.6002 |
Onchocerca volvulus | Heat shock protein 75 kDa, mitochondrial homolog | 0.0294 | 0.1729 | 0.5 |
Leishmania major | heat shock protein 83-1 | 0.0556 | 1 | 1 |
Echinococcus granulosus | endoplasmin | 0.0459 | 0.6946 | 0.6308 |
Trypanosoma brucei | heat shock protein, putative | 0.0556 | 1 | 1 |
Schistosoma mansoni | heat shock protein | 0.0556 | 1 | 1 |
Plasmodium falciparum | heat shock protein 90 | 0.0556 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0556 | 1 | 1 |
Toxoplasma gondii | heat shock protein 75, putative | 0.0294 | 0.1729 | 0.1514 |
Trypanosoma brucei | heat shock protein, putative | 0.0556 | 1 | 1 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0556 | 1 | 1 |
Toxoplasma gondii | heat shock protein HSP90 | 0.0556 | 1 | 1 |
Schistosoma mansoni | endoplasmin | 0.0556 | 1 | 1 |
Treponema pallidum | heat shock protein 90 | 0.0459 | 0.6946 | 0.5 |
Trypanosoma brucei | Heat shock protein 83, putative | 0.0556 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0556 | 1 | 1 |
Echinococcus granulosus | heat shock protein heat shock protein 90 alpha | 0.0451 | 0.6693 | 0.6002 |
Trypanosoma brucei | heat shock protein, putative | 0.0556 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0556 | 1 | 1 |
Schistosoma mansoni | endoplasmin | 0.0556 | 1 | 1 |
Echinococcus multilocularis | heat shock protein 90 | 0.0556 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0556 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0556 | 1 | 1 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.0556 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 1.6 ug ml-1 | Antifungal activity against Candida tropicalis Berkout KCCM 50662 after 1 day by 2-fold broth dilution method | ChEMBL. | 17046257 |
MIC (functional) | = 3.2 ug ml-1 | Antifungal activity against Cryptococcus neoformans KCCM 50564 after 1 day by 2-fold broth dilution method | ChEMBL. | 17046257 |
MIC (functional) | = 3.2 ug ml-1 | Antifungal activity against Cryptococcus neoformans KCCM 50564 after 1 day by 2-fold broth dilution method | ChEMBL. | 17046257 |
MIC (functional) | = 6.3 ug ml-1 | Antifungal activity against Candida albicans Berkout KCCM 50235 after 1 day by 2-fold broth dilution method | ChEMBL. | 17046257 |
MIC (functional) | = 6.3 ug ml-1 | Antifungal activity against Candida albicans Berkout KCCM 50235 after 1 day by 2-fold broth dilution method | ChEMBL. | 17046257 |
MIC (functional) | = 25 ug ml-1 | Antifungal activity against Candida krusei Berkout KCCM 11655 after 1 day by 2-fold broth dilution method | ChEMBL. | 17046257 |
MIC (functional) | = 25 ug ml-1 | Antifungal activity against Aspergillus niger KCTC 1231 after 2 days by 2-fold broth dilution method | ChEMBL. | 17046257 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.