Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | conserved hypothetical protein | Get druggable targets OG5_144688 | All targets in OG5_144688 |
Echinococcus granulosus | hypothetical protein | Get druggable targets OG5_144688 | All targets in OG5_144688 |
Brugia malayi | Serotonin receptor | Get druggable targets OG5_135430 | All targets in OG5_135430 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | hypothetical protein | 0.0842 | 0.1435 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.2001 | 0.7421 | 0.5 |
Onchocerca volvulus | 0.25 | 1 | 0.5 | |
Leishmania major | fatty-acid desaturase, putative | 0.25 | 1 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.25 | 1 | 1 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.2001 | 0.7421 | 0.5 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.2001 | 0.7421 | 0.5 |
Brugia malayi | acyl-CoA desaturase | 0.2001 | 0.7421 | 1 |
Onchocerca volvulus | 0.25 | 1 | 0.5 | |
Trypanosoma brucei | fatty acid desaturase, putative | 0.25 | 1 | 0.5 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0833 | 0.139 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Agonist activity at human 5HT2A receptor expressed in HEK293 cells by measuring intracellular calcium mobilization upto 10 uM | ChEMBL. | 17079142 | |
Activity (functional) | Agonist activity at human 5HT2B receptor expressed in HEK293 cells by measuring intracellular calcium mobilization upto 10 uM | ChEMBL. | 17079142 | |
Activity (functional) | Agonist activity at human 5HT2C receptor expressed in HEK293 cells by measuring intracellular calcium mobilization upto 10 uM | ChEMBL. | 17079142 | |
Activity (functional) | 0 | Agonist activity at human 5HT2A receptor expressed in HEK293 cells by measuring intracellular calcium mobilization upto 10 uM | ChEMBL. | 17079142 |
Activity (functional) | 0 | Agonist activity at human 5HT2B receptor expressed in HEK293 cells by measuring intracellular calcium mobilization upto 10 uM | ChEMBL. | 17079142 |
Activity (functional) | 0 | Agonist activity at human 5HT2C receptor expressed in HEK293 cells by measuring intracellular calcium mobilization upto 10 uM | ChEMBL. | 17079142 |
Ki (binding) | = -7.9 | Displacement of [3H]mesulergine from human 5HT2C receptor expressed in HEK293 cells | ChEMBL. | 17079142 |
Ki (binding) | < -5 | Displacement of [3H]ketanserin from human 5HT2A receptor expressed in HEK293 cells | ChEMBL. | 17079142 |
Ki (binding) | < -5 | Displacement of [3H]5HT from human 5HT2B receptor expressed in HEK293 cells | ChEMBL. | 17079142 |
Log Ki (binding) | < 5 | Displacement of [3H]ketanserin from human 5HT2A receptor expressed in HEK293 cells | ChEMBL. | 17079142 |
Log Ki (binding) | < 5 | Displacement of [3H]5HT from human 5HT2B receptor expressed in HEK293 cells | ChEMBL. | 17079142 |
Log Ki (binding) | = 7.9 | Displacement of [3H]mesulergine from human 5HT2C receptor expressed in HEK293 cells | ChEMBL. | 17079142 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.