Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aldo keto reductase | 0.0454 | 0.2024 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0454 | 0.2024 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0454 | 0.2024 | 0.5 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0454 | 0.2024 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0454 | 0.2024 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0454 | 0.2024 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0454 | 0.2024 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0454 | 0.2024 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0454 | 0.2024 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0454 | 0.2024 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0454 | 0.2024 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0454 | 0.2024 | 0.5 |
Onchocerca volvulus | 0.0973 | 1 | 1 | |
Toxoplasma gondii | aldose reductase, putative | 0.0454 | 0.2024 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0454 | 0.2024 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0454 | 0.2024 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0454 | 0.2024 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0454 | 0.2024 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0454 | 0.2024 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0454 | 0.2024 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0454 | 0.2024 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0454 | 0.2024 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0454 | 0.2024 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0454 | 0.2024 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0792 | 0.7228 | 0.6524 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0454 | 0.2024 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0454 | 0.2024 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0454 | 0.2024 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0454 | 0.2024 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0454 | 0.2024 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0454 | 0.2024 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0454 | 0.2024 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0454 | 0.2024 | 0.5 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0792 | 0.7228 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0454 | 0.2024 | 1 |
Echinococcus granulosus | hypothetical protein | 0.0454 | 0.2024 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0454 | 0.2024 | 1 |
Schistosoma mansoni | pol-related | 0.0454 | 0.2024 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0454 | 0.2024 | 0.5 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0792 | 0.7228 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0454 | 0.2024 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0454 | 0.2024 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0454 | 0.2024 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0792 | 0.7228 | 0.6524 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0454 | 0.2024 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0454 | 0.2024 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0454 | 0.2024 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0454 | 0.2024 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0454 | 0.2024 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0454 | 0.2024 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0454 | 0.2024 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0454 | 0.2024 | 1 |
Leishmania major | fatty-acid desaturase, putative | 0.0973 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0454 | 0.2024 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0454 | 0.2024 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0454 | 0.2024 | 1 |
Onchocerca volvulus | 0.0973 | 1 | 1 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0454 | 0.2024 | 1 |
Giardia lamblia | Aldose reductase | 0.0454 | 0.2024 | 0.5 |
Brugia malayi | acyl-CoA desaturase | 0.0792 | 0.7228 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0454 | 0.2024 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0454 | 0.2024 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0454 | 0.2024 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0454 | 0.2024 | 1 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0973 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0454 | 0.2024 | 1 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0792 | 0.7228 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0973 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0454 | 0.2024 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of tetracycline-induced iNOS expressed in SF9 cells | ChEMBL. | 17368901 | |
IC50 (binding) | 0 | Inhibition of tetracycline-induced iNOS expressed in SF9 cells | ChEMBL. | 17368901 |
IC50 (functional) | > 10000 nM | Inhibition of nitric oxide formation in human A172 cells | ChEMBL. | 17368901 |
Ratio IC50 (binding) | 0 | Selectivity for iNOS over nNOS in tetracycline-induced system | ChEMBL. | 17368901 |
Ratio IC50 (binding) | 0 | Selectivity for iNOS over eNOS in tetracycline-induced system | ChEMBL. | 17368901 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.