Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0143 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0143 | 1 | 0.5 |
Echinococcus granulosus | Tolloid protein 1 | 0.0141 | 0.9742 | 0.973 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0446 | 0.0446 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0141 | 0.9742 | 0.9742 |
Echinococcus granulosus | histone deacetylase 7 | 0.0054 | 0.1256 | 0.0848 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0143 | 1 | 0.5 |
Plasmodium falciparum | histone deacetylase 1 | 0.0143 | 1 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0054 | 0.1256 | 0.1256 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0054 | 0.1256 | 0.0848 |
Echinococcus multilocularis | histone deacetylase | 0.0054 | 0.1256 | 0.0848 |
Giardia lamblia | Histone deacetylase | 0.0143 | 1 | 0.5 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0143 | 1 | 1 |
Brugia malayi | Fibulin-1 precursor | 0.0045 | 0.0446 | 0.0446 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0054 | 0.1256 | 0.1256 |
Echinococcus granulosus | histone deacetylase 6 | 0.0054 | 0.1256 | 0.0848 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0054 | 0.1256 | 0.0848 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0045 | 0.0446 | 0.0446 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1256 | 0.1256 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0143 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0143 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0054 | 0.1256 | 0.0848 |
Leishmania major | histone deacetylase, putative | 0.0143 | 1 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0054 | 0.1256 | 0.1256 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0143 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.1609 | 0.1609 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 1 | 1 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0054 | 0.1256 | 0.1256 |
Echinococcus granulosus | histone deacetylase 6 | 0.0054 | 0.1256 | 0.0848 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0054 | 0.1256 | 0.1256 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0054 | 0.1256 | 0.1256 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0143 | 1 | 0.5 |
Echinococcus granulosus | histone deacetylase 6 | 0.0054 | 0.1256 | 0.0848 |
Brugia malayi | Histone deacetylase family protein | 0.0054 | 0.1256 | 0.1256 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0143 | 1 | 0.5 |
Brugia malayi | histone deacetylase 11 | 0.0054 | 0.1256 | 0.1256 |
Echinococcus granulosus | histone deacetylase 1 | 0.0143 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0143 | 1 | 1 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0054 | 0.1256 | 1 |
Toxoplasma gondii | histone deacetylase HDAC5 | 0.0054 | 0.1256 | 0.0848 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0141 | 0.9742 | 0.973 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0054 | 0.1256 | 0.0848 |
Brugia malayi | Histone deacetylase 1 | 0.0143 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0054 | 0.1256 | 0.0848 |
Schistosoma mansoni | histone deacetylase | 0.0143 | 1 | 1 |
Leishmania major | histone deacetylase, putative | 0.0143 | 1 | 1 |
Entamoeba histolytica | histone deacetylase, putative | 0.0143 | 1 | 0.5 |
Loa Loa (eye worm) | AStacin protease | 0.0088 | 0.4599 | 0.4599 |
Echinococcus granulosus | histone deacetylase 8 | 0.0054 | 0.1256 | 0.0848 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0143 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.9184 | 0.9184 |
Loa Loa (eye worm) | histone deacetylase | 0.0054 | 0.1256 | 0.1256 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0141 | 0.9742 | 0.9742 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0143 | 1 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0143 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0054 | 0.1256 | 0.0848 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0045 | 0.0446 | 0.0446 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0054 | 0.1256 | 0.1256 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0143 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0143 | 1 | 0.5 |
Toxoplasma gondii | histone deacetylase HDAC4 | 0.0054 | 0.1256 | 0.0848 |
Echinococcus granulosus | histone deacetylase 3 | 0.0143 | 1 | 1 |
Echinococcus granulosus | histone deacetylase | 0.0054 | 0.1256 | 0.0848 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0143 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0143 | 1 | 0.5 |
Trypanosoma brucei | histone deacetylase 1 | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0143 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0143 | 1 | 0.5 |
Brugia malayi | Histone deacetylase family protein | 0.0054 | 0.1256 | 0.1256 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | > 100 uM | Cytotoxicity against Huh7 cells by MTS assay | ChEMBL. | 17482818 |
IC50 (functional) | = 1.6 uM | Inhibition of HCV replicon RNA production in HUh7 cells | ChEMBL. | 17482818 |
Ki (binding) | = 0.64 uM | Inhibition of HCV NS3 4A protease | ChEMBL. | 17482818 |
Selectivity index (functional) | > 64 | Selectivity index, ratio of CC50 for Huh7cells to IC50 for HCV | ChEMBL. | 17482818 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.