Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon receptor | 477 aa | 457 aa | 25.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Arrow homolog | 0.0087 | 0.1882 | 1 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0087 | 0.1882 | 0.8351 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0087 | 0.1882 | 0.1882 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0097 | 0.2253 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.1882 | 0.1882 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0097 | 0.2253 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.3223 | 0.3223 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.9535 | 0.9535 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0301 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.085 | 0.085 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0097 | 0.2253 | 0.2253 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.085 | 0.377 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.085 | 0.377 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0127 | 0.0563 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0301 | 1 | 1 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0301 | 1 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0097 | 0.2253 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.085 | 0.085 |
Brugia malayi | Fibulin-1 precursor | 0.0097 | 0.2253 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.1882 | 0.1882 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0127 | 0.0127 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.2253 | 0.2253 |
Loa Loa (eye worm) | AStacin protease | 0.0188 | 0.5714 | 0.5714 |
Schistosoma mansoni | egf-like domain protein | 0.0087 | 0.1882 | 0.1777 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | Antagonist activity at human GIP receptor transfected in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation | ChEMBL. | 17126016 | |
IC50 (functional) | 0 | Antagonist activity at human GIP receptor transfected in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation | ChEMBL. | 17126016 |
IC50 (binding) | = 130 nM | Displacement of [125]glucagon from human glucagon receptor expressed in CHO cells | ChEMBL. | 17126016 |
IC50 (binding) | = 130 nM | Displacement of [125]glucagon from human glucagon receptor expressed in CHO cells | ChEMBL. | 17126016 |
IC50 (functional) | = 2778 nM | Antagonist activity at human glucagon receptor transfected in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation | ChEMBL. | 17126016 |
IC50 (functional) | = 2778 nM | Antagonist activity at human glucagon receptor transfected in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation | ChEMBL. | 17126016 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.