Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Pim-1 proto-oncogene, serine/threonine kinase | Starlite/ChEMBL | References |
Homo sapiens | baculoviral IAP repeat containing 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.0357 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0192 | 0.364 | 1 |
Onchocerca volvulus | Deterin homolog | 0.0357 | 1 | 1 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.0192 | 0.364 | 0.364 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.0192 | 0.364 | 0.364 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.0192 | 0.364 | 0.364 |
Loa Loa (eye worm) | hypothetical protein | 0.0357 | 1 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0192 | 0.364 | 0.364 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.0192 | 0.364 | 0.364 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0192 | 0.364 | 0.364 |
Brugia malayi | Protein kinase domain containing protein | 0.0192 | 0.364 | 0.364 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.0357 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 50 nM | Inhibition of Pim1 after 15 mins by scintillation counting-based competition assay in presence of 25 uM [gamma33P]ATP | ChEMBL. | 19256503 |
IC50 (binding) | = 50 nM | Inhibition of Pim1 assessed as [32P] incorporation preincubated for 15 mins before ATP substrate addition by coupled spectrophotometric assay | ChEMBL. | 19414255 |
IC50 (binding) | = 50 nmol | Inhibition of PIM1 | ChEMBL. | 19836860 |
IC50 (binding) | = 0.05 uM | Inhibition of Pim1 kinase | ChEMBL. | 17251021 |
IC50 (binding) | = 0.05 uM | Inhibition of Pim1 kinase | ChEMBL. | 17251021 |
IC50 (binding) | = 0.05 uM | Competitive inhibition of PIM1 in presence of ATP | ChEMBL. | 22924342 |
IC50 (binding) | > 20 uM | Inhibition of Pim2 kinase | ChEMBL. | 17251021 |
IC50 (binding) | > 20 uM | Inhibition of MEK1 kinase | ChEMBL. | 17251021 |
IC50 (binding) | > 20 uM | Inhibition of MEK2 kinase | ChEMBL. | 17251021 |
IC50 (binding) | > 20 uM | Inhibition of Pim2 kinase | ChEMBL. | 17251021 |
IC50 (binding) | > 20 uM | Inhibition of MEK1 kinase | ChEMBL. | 17251021 |
IC50 (binding) | > 20 uM | Inhibition of MEK2 kinase | ChEMBL. | 17251021 |
Kd (binding) | = 5 uM | Binding affinity to human survivin expressed in Escherichia coli BL21 cells after 30 mins | ChEMBL. | 17391963 |
Kd (binding) | = 5 uM | Binding affinity to human survivin expressed in Escherichia coli BL21 cells after 30 mins | ChEMBL. | 17391963 |
Kd (binding) | = 5.7 uM | Inhibition of survivin | ChEMBL. | 19836860 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
6 literature references were collected for this gene.