Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | androgen receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ecdysone induced protein 78C | 0.0009 | 0 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.0563 | 1 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0009 | 0 | 0.5 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0563 | 1 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0563 | 1 | 0.5 |
Onchocerca volvulus | 0.0563 | 1 | 1 | |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0563 | 1 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0009 | 0 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0563 | 1 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0009 | 0 | 0.5 |
Onchocerca volvulus | 0.0563 | 1 | 1 | |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0009 | 0 | 0.5 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0563 | 1 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0009 | 0 | 0.5 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0563 | 1 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0009 | 0 | 0.5 |
Leishmania major | stearic acid desaturase, putative | 0.0563 | 1 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0009 | 0 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0563 | 1 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0009 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.9 nM | Agonist activity at human AR | ChEMBL. | 17267219 |
EC50 (functional) | = 0.9 nM | Agonist activity at human AR | ChEMBL. | 17267219 |
Efficacy (functional) | < 20 % | Antagonist activity at human AR assessed as inhibition of DHT-induced response | ChEMBL. | 17267219 |
Efficacy (functional) | < 20 % | Antagonist activity at human AR assessed as inhibition of DHT-induced response | ChEMBL. | 17267219 |
Efficacy (functional) | = 107 % | Agonist activity at human AR relative to DHT | ChEMBL. | 17267219 |
Efficacy (functional) | = 107 % | Agonist activity at human AR relative to DHT | ChEMBL. | 17267219 |
Fold change (binding) | = 1000 | Selectivity for human AR receptor over estrogen receptor | ChEMBL. | 17267219 |
Fold change (binding) | = 1000 | Selectivity for human AR receptor over progesterone receptor | ChEMBL. | 17267219 |
Fold change (binding) | = 1000 | Selectivity for human AR receptor over glucocorticoid receptor | ChEMBL. | 17267219 |
Fold change (binding) | = 1000 | Selectivity for human AR receptor over mineralocorticoid receptor | ChEMBL. | 17267219 |
IC50 (functional) | > 10000 nM | Antagonist activity at human AR | ChEMBL. | 17267219 |
IC50 (functional) | > 10000 nM | Antagonist activity at human AR | ChEMBL. | 17267219 |
Ki (binding) | = 2.9 nM | Binding affinity to human AR | ChEMBL. | 17267219 |
Ki (binding) | = 2.9 nM | Binding affinity to human AR | ChEMBL. | 17267219 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.