TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 666.831 | Formula: C34H46N6O6S
H donors: 6 H acceptors: 6 LogP: 2.62 Rotable bonds: 18
Rule of 5 violations (Lipinski): 3
SMILES: CSCCC(C(=O)N)NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)C1CC2(C)C(C(N1C)Cc1c2cc(O)cc1)C
InChi: 1S/C34H46N6O6S/c1-20-27-15-22-10-11-23(41)16-24(22)34(20,2)17-28(40(27)3)33(46)37-18-29(42)36-19-30(43)38-26(14-21-8-6-5-7-9-21)32(45)39-25(31(35)44)12-13-47-4/h5-11,16,20,25-28,41H,12-15,17-19H2,1-4H3,(H2,35,44)(H,36,42)(H,37,46)(H,38,43)(H,39,45)
InChiKey: XDEWTAYBHFQFTJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	ecdysone induced protein 78C	0.0092	0.2324	0.2324
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Echinococcus granulosus	SHC transforming protein 3	0.0105	0.3574	0.3574
Onchocerca volvulus		0.0173	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0092	0.2324	0.2324
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0092	0.2324	0.2324
Brugia malayi	SRC-1	0.0173	1	1
Loa Loa (eye worm)	hypothetical protein	0.0105	0.3574	0.3574
Schistosoma mansoni	tyrosine kinase	0.0173	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0092	0.2324	0.2324
Loa Loa (eye worm)	hypothetical protein	0.0092	0.2324	0.2324
Giardia lamblia	Protein 21.1	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0105	0.3574	0.3574
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0092	0.2324	0.2324
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0105	0.3574	0.3574
Loa Loa (eye worm)	TK/FER protein kinase	0.0173	1	1
Brugia malayi	ecdysteroid receptor	0.0092	0.2324	0.2324
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0092	0.2324	0.2324
Schistosoma mansoni	nck2/grb4	0.0105	0.3574	0.3574
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0068	0	0.5
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0092	0.2324	0.2324
Echinococcus granulosus	tyrosine kinase	0.0173	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0092	0.2324	0.2324
Loa Loa (eye worm)	hypothetical protein	0.0092	0.2324	0.2324
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0105	0.3574	0.3574
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0092	0.2324	0.2324
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0173	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0105	0.3574	0.3574
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0092	0.2324	0.2324
Brugia malayi	SH2 domain containing protein	0.0173	1	1
Onchocerca volvulus		0.0092	0.2324	0.2324
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0092	0.2324	0.2324
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0105	0.3574	0.3574
Loa Loa (eye worm)	hypothetical protein	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0173	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0092	0.2324	0.2324
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0173	1	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0092	0.2324	0.2324
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0092	0.2324	0.2324
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Trichomonas vaginalis	TK family protein kinase	0.0068	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0105	0.3574	0.3574
Loa Loa (eye worm)	TK/FER protein kinase	0.0173	1	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0173	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0173	1	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0105	0.3574	0.3574
Echinococcus granulosus	growth factor receptor bound protein 2	0.0105	0.3574	0.3574
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0173	1	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0092	0.2324	0.2324
Echinococcus granulosus	hypothetical protein	0.0105	0.3574	0.3574
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0105	0.3574	0.3574
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0092	0.2324	0.2324
Toxoplasma gondii	STE kinase	0.0068	0	0.5
Echinococcus granulosus	tyrosine protein kinase shark	0.0173	1	1
Echinococcus granulosus	SH2 domain containing protein 7	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0173	1	1
Brugia malayi	nuclear hormone receptor	0.0092	0.2324	0.2324
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0092	0.2324	0.2324
Loa Loa (eye worm)	TK/FER protein kinase	0.0173	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0105	0.3574	0.3574
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0105	0.3574	0.3574
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0105	0.3574	0.3574
Brugia malayi	protein-tyrosine kinase	0.0173	1	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0173	1	1
Loa Loa (eye worm)	hypothetical protein	0.0105	0.3574	0.3574
Loa Loa (eye worm)	hypothetical protein	0.0105	0.3574	0.3574
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0092	0.2324	0.2324
Echinococcus multilocularis	NCK adaptor protein	0.0105	0.3574	0.3574
Loa Loa (eye worm)	TK/FER protein kinase	0.0173	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0105	0.3574	0.3574
Brugia malayi	Steroid receptor seven-up type 2	0.0092	0.2324	0.2324
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0092	0.2324	0.2324
Echinococcus granulosus	c src tyrosine kinase	0.0173	1	1
Schistosoma mansoni	hypothetical protein	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Echinococcus granulosus	N chimaerin	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Echinococcus multilocularis		0.0105	0.3574	0.3574
Loa Loa (eye worm)	hypothetical protein	0.0092	0.2324	0.2324
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Echinococcus granulosus	tyrosine kinase	0.0173	1	1
Onchocerca volvulus		0.0173	1	1
Loa Loa (eye worm)	hypothetical protein	0.0105	0.3574	0.3574
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0092	0.2324	0.2324
Toxoplasma gondii	protein kinase	0.0068	0	0.5
Schistosoma mansoni	tensin-related	0.0105	0.3574	0.3574
Leishmania major	protein kinase, putative	0.0068	0	0.5
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0068	0	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Echinococcus granulosus	tyrosine protein kinase Blk	0.0173	1	1
Giardia lamblia	Kinase, NEK	0.0068	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Onchocerca volvulus		0.0105	0.3574	0.3574
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0092	0.2324	0.2324
Loa Loa (eye worm)	hypothetical protein	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Schistosoma mansoni	RAR-like nuclear receptor	0.0092	0.2324	0.2324
Onchocerca volvulus		0.0173	1	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0105	0.3574	0.3574
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0173	1	1
Toxoplasma gondii	protein kinase domain-containing protein	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0092	0.2324	0.2324
Loa Loa (eye worm)	hypothetical protein	0.0105	0.3574	0.3574
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0173	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0105	0.3574	0.3574
Schistosoma mansoni	tensin	0.0105	0.3574	0.3574
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0092	0.2324	0.2324
Brugia malayi	Protein kinase domain containing protein	0.0173	1	1
Leishmania major	hypothetical protein, conserved	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0105	0.3574	0.3574
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0173	1	1
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0105	0.3574	0.3574
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0105	0.3574	0.3574
Echinococcus granulosus	NCK adaptor protein	0.0105	0.3574	0.3574
Echinococcus multilocularis	N chimaerin	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0092	0.2324	0.2324
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0105	0.3574	0.3574
Schistosoma mansoni	growth factor receptor-bound protein	0.0105	0.3574	0.3574
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0105	0.3574	0.3574
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0	0.5
Schistosoma mansoni	tensin-related	0.0105	0.3574	0.3574
Schistosoma mansoni	tensin	0.0105	0.3574	0.3574
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0173	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0173	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0092	0.2324	0.2324
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0105	0.3574	0.3574
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0173	1	1
Echinococcus multilocularis	SH2 motif	0.0105	0.3574	0.3574
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0068	0	0.5
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0105	0.3574	0.3574
Echinococcus multilocularis	signal transduction protein lnk realted	0.0105	0.3574	0.3574
Leishmania major	protein kinase, putative	0.0068	0	0.5
Echinococcus multilocularis	tyrosine protein kinase shark	0.0173	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0173	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Schistosoma mansoni	signal transduction protein lnk-related	0.0105	0.3574	0.3574
Entamoeba histolytica	protein kinase, putative	0.0105	0.3574	0.3574
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0068	0	0.5
Echinococcus multilocularis	tensin	0.0105	0.3574	0.3574
Schistosoma mansoni	tyrosine kinase	0.0173	1	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0092	0.2324	0.2324
Schistosoma mansoni	nuclear hormone receptor	0.0092	0.2324	0.2324
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0105	0.3574	0.3574
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0092	0.2324	0.2324
Onchocerca volvulus		0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0173	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0105	0.3574	0.3574
Schistosoma mansoni	shc transforming protein	0.0105	0.3574	0.3574
Giardia lamblia	Kinase	0.0068	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0092	0.2324	0.2324
Onchocerca volvulus	Protein ultraspiracle homolog	0.0092	0.2324	0.2324
Schistosoma mansoni	suppressor of cytokine signaling	0.0105	0.3574	0.3574
Echinococcus granulosus	tensin	0.0105	0.3574	0.3574
Schistosoma mansoni	tyrosine kinase	0.0173	1	1
Loa Loa (eye worm)	hypothetical protein	0.0105	0.3574	0.3574
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0173	1	1
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0105	0.3574	0.3574
Onchocerca volvulus		0.0105	0.3574	0.3574
Onchocerca volvulus		0.0173	1	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Echinococcus granulosus	signal transduction protein lnk realted	0.0105	0.3574	0.3574
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0173	1	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0173	1	1
Echinococcus multilocularis	SH2 motif	0.0105	0.3574	0.3574
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0068	0	0.5
Schistosoma mansoni	thyroid hormone receptor	0.0092	0.2324	0.2324
Onchocerca volvulus		0.0173	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0092	0.2324	0.2324
Brugia malayi	Variant SH3 domain containing protein	0.0105	0.3574	0.3574
Brugia malayi	Protein kinase domain containing protein	0.0173	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0105	0.3574	0.3574
Schistosoma mansoni	GTPase activating protein	0.0105	0.3574	0.3574
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0092	0.2324	0.2324
Brugia malayi	Tyrosine-protein kinase abl-1	0.0173	1	1
Schistosoma mansoni	vav2	0.0105	0.3574	0.3574
Loa Loa (eye worm)	SH2 domain-containing protein	0.0105	0.3574	0.3574
Loa Loa (eye worm)	hypothetical protein	0.0105	0.3574	0.3574
Loa Loa (eye worm)	TK/ABL protein kinase	0.0173	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0105	0.3574	0.3574
Trypanosoma cruzi	protein kinase, putative	0.0068	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0173	1	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0092	0.2324	0.2324
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0092	0.2324	0.2324
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0105	0.3574	0.3574
Trichomonas vaginalis	protein kinase atn1, putative	0.0068	0	0.5
Loa Loa (eye worm)	STAT protein	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Trypanosoma brucei	Pseudokinase, putative	0.0068	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0092	0.2324	0.2324
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0092	0.2324	0.2324
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0092	0.2324	0.2324
Entamoeba histolytica	SH2 domain containing protein	0.0105	0.3574	0.3574
Onchocerca volvulus		0.0105	0.3574	0.3574
Brugia malayi	SH2 domain containing protein	0.0105	0.3574	0.3574
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0105	0.3574	0.3574
Schistosoma mansoni	tyrosine kinase	0.0173	1	1
Onchocerca volvulus		0.0173	1	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0092	0.2324	0.2324
Schistosoma mansoni	coup transcription factor	0.0092	0.2324	0.2324
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Loa Loa (eye worm)	steroid hormone receptor	0.0092	0.2324	0.2324
Echinococcus granulosus	expressed conserved protein	0.0105	0.3574	0.3574
Brugia malayi	SH2 domain containing protein	0.0173	1	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0092	0.2324	0.2324
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0173	1	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0068	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0092	0.2324	0.2324
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0173	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0173	1	1
Echinococcus multilocularis	SHC transforming protein 3	0.0105	0.3574	0.3574
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0173	1	1
Brugia malayi	nuclear receptor NHR-88	0.0092	0.2324	0.2324
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0173	1	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0068	0	0.5
Brugia malayi	hypothetical protein	0.0173	1	1
Brugia malayi	Tensin	0.0105	0.3574	0.3574
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0092	0.2324	0.2324
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0105	0.3574	0.3574
Loa Loa (eye worm)	TK protein kinase	0.0173	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0092	0.2324	0.2324
Echinococcus granulosus	FTZ F1 alpha	0.0092	0.2324	0.2324
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0068	0	0.5
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Brugia malayi	SH2 domain containing protein	0.0105	0.3574	0.3574
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0092	0.2324	0.2324
Brugia malayi	steroid hormone receptor	0.0092	0.2324	0.2324
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0173	1	1
Echinococcus multilocularis	tensin	0.0105	0.3574	0.3574
Schistosoma mansoni	suppressor of cytokine signaling	0.0105	0.3574	0.3574
Schistosoma mansoni	hypothetical protein	0.0105	0.3574	0.3574
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0173	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Brugia malayi	Sex muscle abnormal protein 5	0.0105	0.3574	0.3574
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0068	0	0.5
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.0105	0.3574	0.3574
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0173	1	1
Plasmodium vivax	protein kinase, putative	0.0068	0	0.5
Echinococcus granulosus	SH2 motif	0.0105	0.3574	0.3574
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0068	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0173	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Echinococcus granulosus	SH2 motif	0.0105	0.3574	0.3574
Onchocerca volvulus	Bile acid receptor homolog	0.0092	0.2324	0.2324
Loa Loa (eye worm)	hypothetical protein	0.0105	0.3574	0.3574
Plasmodium falciparum	protein kinase, putative	0.0068	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0105	0.3574	0.3574
Brugia malayi	RhoGAP domain containing protein	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Brugia malayi	SH2 domain containing protein	0.0105	0.3574	0.3574
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0173	1	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0105	0.3574	0.3574
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0173	1	1
Echinococcus multilocularis	tyrosine kinase	0.0173	1	1
Brugia malayi	SH2 domain containing protein	0.0105	0.3574	0.3574
Schistosoma mansoni	thyroid hormone receptor	0.0092	0.2324	0.2324
Brugia malayi	SH2 domain containing protein	0.0105	0.3574	0.3574
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0173	1	1
Schistosoma mansoni	tyrosine kinase	0.0173	1	1
Echinococcus multilocularis	SH2 motif	0.0105	0.3574	0.3574
Plasmodium falciparum	protein kinase, putative	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0173	1	1
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Giardia lamblia	Kinase, NEK	0.0068	0	0.5
Schistosoma mansoni	SH2A	0.0105	0.3574	0.3574
Trichomonas vaginalis	STE family protein kinase	0.0068	0	0.5
Echinococcus multilocularis	FTZ F1 alpha	0.0092	0.2324	0.2324
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0173	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Echinococcus granulosus	tyrosine protein kinase Srms	0.0173	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0068	0	0.5
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0068	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Onchocerca volvulus		0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0068	0	0.5
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0068	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0092	0.2324	0.2324
Schistosoma mansoni	tyrosine kinase	0.0173	1	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0068	0	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0092	0.2324	0.2324
Echinococcus multilocularis	SH2 domain containing protein 7	0.0105	0.3574	0.3574
Loa Loa (eye worm)	TK/FER protein kinase	0.0173	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0173	1	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0092	0.2324	0.2324
Loa Loa (eye worm)	hypothetical protein	0.0105	0.3574	0.3574
Loa Loa (eye worm)	SRC-1	0.0173	1	1
Brugia malayi	SH2 domain containing protein	0.0105	0.3574	0.3574
Brugia malayi	SH2 domain containing protein	0.0105	0.3574	0.3574
Loa Loa (eye worm)	hypothetical protein	0.0092	0.2324	0.2324
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0105	0.3574	0.3574
Trypanosoma brucei	protein kinase, putative	0.0068	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0173	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0105	0.3574	0.3574
Echinococcus multilocularis	c src tyrosine kinase	0.0173	1	1
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0105	0.3574	0.3574
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0092	0.2324	0.2324
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0173	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0	0.5
Schistosoma mansoni	retinoic acid receptor RXR	0.0092	0.2324	0.2324
Schistosoma mansoni	tensin	0.0105	0.3574	0.3574
Schistosoma mansoni	adapter molecule crk	0.0105	0.3574	0.3574
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0105	0.3574	0.3574
Echinococcus granulosus	ecdysone induced protein 78C	0.0092	0.2324	0.2324
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0068	0	0.5
Trypanosoma cruzi	protein kinase, putative	0.0068	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0092	0.2324	0.2324
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0105	0.3574	0.3574
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0092	0.2324	0.2324
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Onchocerca volvulus		0.0105	0.3574	0.3574
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0105	0.3574	0.3574
Loa Loa (eye worm)	hypothetical protein	0.0092	0.2324	0.2324
Brugia malayi	hypothetical protein	0.0105	0.3574	0.3574
Brugia malayi	Protein kinase domain containing protein	0.0173	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0068	0	0.5
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0092	0.2324	0.2324

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0.00000797 M	Mu opioid receptor agonist activity as inhibition of electrically stimulated mysenteric plexus in guinea pig ileum	ChEMBL.	7154002
Relative potency (functional)	0	Mu opioid receptor agonist activity was determined by inhibition of electrically stimulated myenteric plexus in guinea pig ileum; Inactive	ChEMBL.	7154002
Relative potency (functional)	= 0.007	Mu opioid receptor agonist activity was determined by inhibition of electrically stimulated myenteric plexus in guinea pig ileum	ChEMBL.	7154002

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 145332

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 44133