Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0691 | 0.0691 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0691 | 0.0691 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0039 | 0.0307 | 0.0307 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0075 | 0.0691 | 0.0691 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0033 | 0.0247 | 0.21 |
Trypanosoma cruzi | oligopeptidase b | 0.0075 | 0.0691 | 0.1779 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0075 | 0.0691 | 1 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0317 | 0.3289 | 0.3289 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0036 | 0.0272 | 0.0272 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0128 | 0.0128 |
Brugia malayi | Serine protease Z688.6 precursor | 0.0022 | 0.0128 | 0.0128 |
Echinococcus granulosus | acylamino acid releasing enzyme | 0.0075 | 0.0691 | 0.0691 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0075 | 0.0691 | 0.1779 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0128 | 0.0128 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0033 | 0.0247 | 0.21 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0317 | 0.3289 | 1 |
Schistosoma mansoni | acylaminoacyl-peptidase (S09 family) | 0.0075 | 0.0691 | 0.0691 |
Brugia malayi | Serine carboxypeptidase S28 family protein | 0.0022 | 0.0128 | 0.0128 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0075 | 0.0691 | 1 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0075 | 0.0691 | 0.0569 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0943 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0075 | 0.0691 | 0.0691 |
Plasmodium vivax | hypothetical protein, conserved | 0.0075 | 0.0691 | 0.5 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0415 | 0.4342 | 0.4342 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.0075 | 0.0691 | 0.1779 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0317 | 0.3289 | 0.3289 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.0415 | 0.4342 | 0.4342 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0075 | 0.0691 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0221 | 0.0221 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0036 | 0.0272 | 0.0272 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.0022 | 0.0128 | 0.0128 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0075 | 0.0691 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0691 | 0.0691 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0075 | 0.0691 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0075 | 0.0691 | 0.1779 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.2487 | 0.2487 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0075 | 0.0691 | 0.5 |
Brugia malayi | Serine protease Z688.6 precursor | 0.0022 | 0.0128 | 0.0128 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0075 | 0.0691 | 0.0691 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0317 | 0.3289 | 1 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.0075 | 0.0691 | 0.1779 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0075 | 0.0691 | 1 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0317 | 0.3289 | 1 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0075 | 0.0691 | 0.1779 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0075 | 0.0691 | 0.0691 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0075 | 0.0691 | 0.5 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0943 | 1 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0075 | 0.0691 | 1 |
Brugia malayi | hypothetical protein | 0.0242 | 0.2487 | 0.2487 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0317 | 0.3289 | 0.3289 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0036 | 0.0272 | 0.0272 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0039 | 0.0307 | 0.0307 |
Echinococcus granulosus | prolyl endopeptidase | 0.0075 | 0.0691 | 0.0691 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.0415 | 0.4342 | 0.4342 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0128 | 0.0128 |
Plasmodium falciparum | peptidase, putative | 0.0075 | 0.0691 | 0.5 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0075 | 0.0691 | 0.0691 |
Mycobacterium tuberculosis | Probable peptidase | 0.0075 | 0.0691 | 0.5 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0075 | 0.0691 | 0.0691 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0317 | 0.3289 | 0.3289 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0128 | 0.0128 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0317 | 0.3289 | 1 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0075 | 0.0691 | 0.5 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0022 | 0.0128 | 0.0128 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0075 | 0.0691 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0943 | 1 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0036 | 0.0272 | 0.0272 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0075 | 0.0691 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0075 | 0.0691 | 0.1779 |
Toxoplasma gondii | acylaminoacyl-peptidase, putative | 0.0075 | 0.0691 | 0.1779 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0317 | 0.3289 | 1 |
Toxoplasma gondii | prolyl endopeptidase | 0.0075 | 0.0691 | 0.1779 |
Trypanosoma cruzi | oligopeptidase b | 0.0075 | 0.0691 | 0.1779 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0075 | 0.0691 | 0.0691 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0943 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0075 | 0.0691 | 0.0691 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0075 | 0.0691 | 1 |
Echinococcus multilocularis | acylamino acid releasing enzyme | 0.0075 | 0.0691 | 0.0691 |
Schistosoma mansoni | lysosomal Pro-Xaa carboxypeptidase (S28 family) | 0.0022 | 0.0128 | 0.0128 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0075 | 0.0691 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0317 | 0.3289 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0943 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 30.7 mm | Effect on growth of Raphanus sativus assessed as length of hypocotyl at 50 ug/mL by seed germination assay | ChEMBL. | 17300931 |
IZ (functional) | = 8 mm | Growth inhibition of Verticillium lamellicola at 50 ug/mL | ChEMBL. | 17300931 |
MIC (functional) | = 0.4 ug ml-1 | Antifungal activity against Alternaria brassicae | ChEMBL. | 17300931 |
MIC (functional) | = 0.5 ug ml-1 | Antifungal activity against Alternaria brassicola | ChEMBL. | 17300931 |
MIC (functional) | = 0.5 ug ml-1 | Antifungal activity against Aspergillus flavus | ChEMBL. | 17300931 |
MIC (functional) | = 0.5 ug ml-1 | Antifungal activity against Fusarium oxysporum | ChEMBL. | 17300931 |
MIC (functional) | = 0.5 ug ml-1 | Antifungal activity against Verticillium lamellicola | ChEMBL. | 17300931 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.