Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | 0 | Activity at nAch receptor in american cockroach neurons assessed as induction of inward current at 10 uM by whole-cell patch clamp method | ChEMBL. | 17583505 |
MLD (functional) | = 6.4 10^-8mol | Insecticidal activity against american cockroach after 24 hrs | ChEMBL. | 17583505 |
t1/2 | = 630 min | Chemical stability assessed as half life of hydrolysis of the compound in physiological solution at pH 7.6 | ChEMBL. | 17583505 |
t1/2 | = 635 min | Chemical stability assessed as half life of hydrolysis of the compound in alkaline buffer at pH 8.3 | ChEMBL. | 17583505 |
t1/2 | > 2880 min | Chemical stability assessed as half life of hydrolysis of the compound in acidic buffer at pH 5.4 | ChEMBL. | 17583505 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.