Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cytosolic malate dehydrogenase | 0.0322 | 0.9244 | 0.9244 |
Trypanosoma cruzi | cytosolic malate dehydrogenase, putative | 0.0322 | 0.9244 | 1 |
Trypanosoma cruzi | glycosomal malate dehydrogenase, putative | 0.0295 | 0.8 | 0.7271 |
Echinococcus multilocularis | L lactate dehydrogenase B chain | 0.0339 | 1 | 1 |
Leishmania major | mitochondrial malate dehydrogenase | 0.0295 | 0.8 | 0.6237 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0322 | 0.9244 | 1 |
Chlamydia trachomatis | malate dehydrogenase | 0.0322 | 0.9244 | 0.5 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0322 | 0.9244 | 1 |
Trypanosoma brucei | mitochondrial malate dehydrogenase | 0.0295 | 0.8 | 0.7271 |
Toxoplasma gondii | lactate dehydrogenase LDH2 | 0.0339 | 1 | 0.5 |
Leishmania major | glycosomal malate dehydrogenase | 0.0295 | 0.8 | 0.6237 |
Trypanosoma cruzi | cytosolic malate dehydrogenase, putative | 0.0322 | 0.9244 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0322 | 0.9244 | 1 |
Trichomonas vaginalis | malate and lactate dehydrogenase, putative | 0.0322 | 0.9244 | 1 |
Mycobacterium tuberculosis | Probable malate dehydrogenase Mdh | 0.0322 | 0.9244 | 0.5 |
Toxoplasma gondii | lactate dehydrogenase LDH1 | 0.0339 | 1 | 0.5 |
Echinococcus granulosus | lactate dehydrogenase protein | 0.0339 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | malate dehydrogenase | 0.0339 | 1 | 0.5 |
Trichomonas vaginalis | malate and lactate dehydrogenase, putative | 0.0322 | 0.9244 | 1 |
Echinococcus granulosus | lactate dehydrogenase a | 0.0339 | 1 | 1 |
Leishmania major | malate dehydrogenase, putative | 0.0339 | 1 | 1 |
Brugia malayi | Probable malate dehydrogenase, mitochondrial precursor | 0.0295 | 0.8 | 0.7719 |
Leishmania major | malate dehydrogenase | 0.0295 | 0.8 | 0.6237 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0322 | 0.9244 | 1 |
Trichomonas vaginalis | malate and lactate dehydrogenase, putative | 0.0322 | 0.9244 | 1 |
Echinococcus multilocularis | lactate dehydrogenase a | 0.0339 | 1 | 1 |
Echinococcus granulosus | malate dehydrogenase | 0.0295 | 0.8 | 0.8 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0322 | 0.9244 | 1 |
Loa Loa (eye worm) | malate dehydrogenase | 0.0295 | 0.8 | 0.7719 |
Schistosoma mansoni | malate dehydrogenase | 0.0322 | 0.9244 | 0.8579 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0221 | 0.4684 | 0.1107 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0322 | 0.9244 | 1 |
Giardia lamblia | Malate dehydrogenase | 0.0322 | 0.9244 | 0.5 |
Echinococcus multilocularis | malate dehydrogenase | 0.0295 | 0.8 | 0.8 |
Echinococcus granulosus | L lactate dehydrogenase B chain | 0.0339 | 1 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0322 | 0.9244 | 1 |
Trypanosoma brucei | glycosomal malate dehydrogenase | 0.0295 | 0.8 | 0.7271 |
Echinococcus granulosus | cytosolic malate dehydrogenase | 0.0322 | 0.9244 | 0.9244 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0322 | 0.9244 | 1 |
Echinococcus multilocularis | lactate dehydrogenase protein | 0.0339 | 1 | 1 |
Loa Loa (eye worm) | malate dehydrogenase | 0.0322 | 0.9244 | 0.9138 |
Echinococcus multilocularis | cytosolic malate dehydrogenase | 0.0322 | 0.9244 | 0.9244 |
Leishmania major | cytosolic malate dehydrogenase | 0.0322 | 0.9244 | 0.8579 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0322 | 0.9244 | 1 |
Echinococcus multilocularis | malate dehydrogenase | 0.0295 | 0.8 | 0.8 |
Schistosoma mansoni | malate dehydrogenase | 0.0339 | 1 | 1 |
Plasmodium vivax | lactate dehydrogenase | 0.0339 | 1 | 1 |
Schistosoma mansoni | L-lactate dehydrogenase | 0.0339 | 1 | 1 |
Plasmodium vivax | malate dehydrogenase, putative | 0.0339 | 1 | 1 |
Toxoplasma gondii | malate dehydrogenase MDH | 0.0339 | 1 | 0.5 |
Plasmodium falciparum | malate dehydrogenase | 0.0339 | 1 | 1 |
Echinococcus multilocularis | cytosolic malate dehydrogenase | 0.0322 | 0.9244 | 0.9244 |
Echinococcus multilocularis | muscleblind protein | 0.0145 | 0.1228 | 0.1228 |
Trypanosoma brucei | cytosolic malate dehydrogenase | 0.0322 | 0.9244 | 1 |
Trypanosoma cruzi | malate dehydrogenase, putative | 0.0295 | 0.8 | 0.7271 |
Schistosoma mansoni | malate dehydrogenase | 0.0322 | 0.9244 | 0.8579 |
Echinococcus granulosus | lactate dehydrogenase a | 0.0339 | 1 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0145 | 0.1228 | 0.1228 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0322 | 0.9244 | 1 |
Mycobacterium ulcerans | malate dehydrogenase | 0.0322 | 0.9244 | 0.5 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0322 | 0.9244 | 1 |
Plasmodium falciparum | L-lactate dehydrogenase | 0.0339 | 1 | 1 |
Brugia malayi | Malate dehydrogenase, cytoplasmic | 0.0322 | 0.9244 | 0.9138 |
Entamoeba histolytica | malate dehydrogenase, putative | 0.0339 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0145 | 0.1228 | 0.1228 |
Echinococcus multilocularis | lactate dehydrogenase a | 0.0339 | 1 | 1 |
Echinococcus granulosus | malate dehydrogenase | 0.0295 | 0.8 | 0.8 |
Trypanosoma cruzi | mitochondrial malate dehydrogenase, putative | 0.0295 | 0.8 | 0.7271 |
Echinococcus multilocularis | lactate dehydrogenase a | 0.0339 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0339 | 1 | 1 |
Schistosoma mansoni | malate dehydrogenase | 0.0295 | 0.8 | 0.6237 |
Trichomonas vaginalis | malate and lactate dehydrogenase, putative | 0.0322 | 0.9244 | 1 |
Mycobacterium leprae | PROBABLE MALATE DEHYDROGENASE MDH | 0.0322 | 0.9244 | 0.5 |
Trypanosoma cruzi | glycosomal malate dehydrogenase, putative | 0.0295 | 0.8 | 0.7271 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.2 uM | Cytotoxicity against human HeLa cells by MTT assay | ChEMBL. | 17574415 |
IC50 (functional) | = 4.88 uM | Cytotoxicity against mouse B16 cells by MTT assay | ChEMBL. | 17574415 |
IC50 (functional) | = 15.06 uM | Cytotoxicity against mouse L1210 cells by MTT assay | ChEMBL. | 17574415 |
Ratio IC50 (functional) | = 2.69 | Ratio of IC50 for mouse L1210 cells to IC50 for mouse L1210 cells in presence of DMFO | ChEMBL. | 17574415 |
Ratio IC50 (functional) | = 3.6 | Ratio of IC50 for mouse B16 cells in presence of SPD to IC50 for mouse B16 cells | ChEMBL. | 17574415 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.