Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, alpha | 451 aa | 372 aa | 25.3 % |
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.1316 | 0.9644 |
Schistosoma mansoni | peroxidasin | 0.0262 | 0.0916 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0301 | 0.1331 | 0.7711 |
Mycobacterium ulcerans | hypothetical protein | 0.1111 | 1 | 1 |
Onchocerca volvulus | 0.0262 | 0.0916 | 0.5 | |
Onchocerca volvulus | 0.0262 | 0.0916 | 0.5 | |
Onchocerca volvulus | Peroxidase homolog | 0.0262 | 0.0916 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0262 | 0.0916 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0262 | 0.0916 | 0.5 |
Mycobacterium ulcerans | 2-nitropropane dioxygenase | 0.1111 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.0262 | 0.0916 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0262 | 0.0916 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0312 | 0.1454 | 1 |
Wolbachia endosymbiont of Brugia malayi | trans-2-enoyl-ACP reductase, FabK | 0.1111 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0301 | 0.1331 | 0.7711 |
Trichomonas vaginalis | 2-nitropropane dioxygenase precursor, putative | 0.1111 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0301 | 0.1331 | 1 |
Mycobacterium tuberculosis | Possible alanine rich oxidoreductase | 0.1111 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0262 | 0.0916 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0262 | 0.0916 | 0.5 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.1111 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0262 | 0.0916 | 1 |
Onchocerca volvulus | 0.0262 | 0.0916 | 0.5 | |
Onchocerca volvulus | Dual oxidase homolog | 0.0262 | 0.0916 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 72 % | Activity against TRAFalpha1 expressed in CHOK1 cells by alkaline phosphatase reporter gene assay | ChEMBL. | 17543524 |
Activity (binding) | = 84 % | Activity against TRAFbeta expressed in CHOK1 cells by alkaline phosphatse reporter gene assay | ChEMBL. | 17543524 |
EC50 (binding) | = 1300 nM | Activity against TRAFbeta expressed in CHOK1 cells by alkaline phosphatse reporter gene assay | ChEMBL. | 17543524 |
EC50 (binding) | = 1500 nM | Activity against TRAFalpha1 expressed in CHOK1 cells by alkaline phosphatase reporter gene assay | ChEMBL. | 17543524 |
IC50 (binding) | = 290 nM | Binding affinity at human thyroid hormone receptor beta1 expressed in CHOK1 cells | ChEMBL. | 17543524 |
IC50 (binding) | = 290 nM | Binding affinity at human thyroid hormone receptor beta1 expressed in CHOK1 cells | ChEMBL. | 17543524 |
IC50 (binding) | = 460 nM | Binding affinity at human thyroid hormone receptor alpha 1 expressed in CHOK1 cells | ChEMBL. | 17543524 |
IC50 (binding) | = 460 nM | Binding affinity at human thyroid hormone receptor alpha 1 expressed in CHOK1 cells | ChEMBL. | 17543524 |
Ratio IC50 (binding) | = 0.9 | Selectivity ratio of IC50 for thyroid hormone receptor alpha1 to IC50 for thyroid hormone receptor beta1 | ChEMBL. | 17543524 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.