Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, alpha | 451 aa | 372 aa | 25.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Animal haem peroxidase family protein | 0.0481 | 0.7993 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0481 | 0.7993 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0481 | 0.7993 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0481 | 0.7993 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0481 | 0.7993 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0557 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0481 | 0.7993 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0481 | 0.7993 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0481 | 0.7993 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0481 | 0.7993 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0481 | 0.7993 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0481 | 0.7993 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0481 | 0.7993 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0481 | 0.7993 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0481 | 0.7993 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0481 | 0.7993 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0481 | 0.7993 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0481 | 0.7993 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0481 | 0.7993 | 1 |
Brugia malayi | Peroxidasin | 0.0481 | 0.7993 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0481 | 0.7993 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0301 | 0.3269 | 0.0076 |
Onchocerca volvulus | 0.0481 | 0.7993 | 0.5 | |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0557 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0481 | 0.7993 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0481 | 0.7993 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0481 | 0.7993 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0481 | 0.7993 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0481 | 0.7993 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0481 | 0.7993 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0481 | 0.7993 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0481 | 0.7993 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0481 | 0.7993 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0481 | 0.7993 | 1 |
Schistosoma mansoni | peroxidasin | 0.0481 | 0.7993 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0481 | 0.7993 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0481 | 0.7993 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0481 | 0.7993 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0312 | 0.3571 | 0.0641 |
Echinococcus granulosus | peroxidasin | 0.0481 | 0.7993 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0481 | 0.7993 | 1 |
Trichomonas vaginalis | 2-nitropropane dioxygenase precursor, putative | 0.0557 | 1 | 0.5 |
Onchocerca volvulus | 0.0481 | 0.7993 | 0.5 | |
Onchocerca volvulus | 0.0481 | 0.7993 | 0.5 | |
Mycobacterium ulcerans | 2-nitropropane dioxygenase | 0.0557 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | trans-2-enoyl-ACP reductase, FabK | 0.0557 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0481 | 0.7993 | 1 |
Mycobacterium tuberculosis | Possible alanine rich oxidoreductase | 0.0557 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 78 % | Activity against TRAFalpha1 expressed in CHOK1 cells by alkaline phosphatase reporter gene assay | ChEMBL. | 17543524 |
Activity (binding) | = 88 % | Activity against TRAFbeta expressed in CHOK1 cells by alkaline phosphatse reporter gene assay | ChEMBL. | 17543524 |
EC50 (binding) | = 11 nM | Activity against TRAFbeta expressed in CHOK1 cells by alkaline phosphatse reporter gene assay | ChEMBL. | 17543524 |
EC50 (binding) | = 17 nM | Activity against TRAFalpha1 expressed in CHOK1 cells by alkaline phosphatase reporter gene assay | ChEMBL. | 17543524 |
IC50 (binding) | = 12 nM | Binding affinity at human thyroid hormone receptor beta1 expressed in CHOK1 cells | ChEMBL. | 17543524 |
IC50 (binding) | = 12 nM | Binding affinity at human thyroid hormone receptor beta1 expressed in CHOK1 cells | ChEMBL. | 17543524 |
IC50 (binding) | = 88 nM | Binding affinity at human thyroid hormone receptor alpha 1 expressed in CHOK1 cells | ChEMBL. | 17543524 |
IC50 (binding) | = 88 nM | Binding affinity at human thyroid hormone receptor alpha 1 expressed in CHOK1 cells | ChEMBL. | 17543524 |
Ratio IC50 (binding) | = 4.3 | Selectivity ratio of IC50 for thyroid hormone receptor alpha1 to IC50 for thyroid hormone receptor beta1 | ChEMBL. | 17543524 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.