Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate NMDA receptor; Grin1/Grin2a | Starlite/ChEMBL | References |
Rattus norvegicus | Vanilloid receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Drosophila melanogaster | NMDA receptor 2 | Glutamate NMDA receptor; Grin1/Grin2a | 938 aa | 878 aa | 27.4 % |
Drosophila melanogaster | Glutamate receptor IA | Glutamate NMDA receptor; Grin1/Grin2a | 938 aa | 979 aa | 23.7 % |
Schistosoma mansoni | glutamate receptor NMDA | Glutamate NMDA receptor; Grin1/Grin2a | 938 aa | 933 aa | 39.1 % |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | Glutamate NMDA receptor; Grin1/Grin2a | 938 aa | 822 aa | 23.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0202 | 0.1449 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0202 | 0.1449 | 0.1387 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0202 | 0.1449 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1094 | 0.8677 | 1 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0023 | 0 | 0.5 |
Giardia lamblia | Kinesin-5 | 0.0163 | 0.1137 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0202 | 0.1449 | 0.5 |
Entamoeba histolytica | kinesin, putative | 0.0163 | 0.1137 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0202 | 0.1449 | 1 |
Plasmodium vivax | kinesin-5 | 0.0163 | 0.1137 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0202 | 0.1449 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0109 | 0.07 | 0.0632 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0202 | 0.1449 | 0.094 |
Brugia malayi | Kinesin motor domain containing protein | 0.0163 | 0.1137 | 0.5835 |
Echinococcus granulosus | carbonic anhydrase | 0.0109 | 0.07 | 0.0632 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0163 | 0.1137 | 0.5835 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0202 | 0.1449 | 0.094 |
Echinococcus multilocularis | carbonic anhydrase | 0.0109 | 0.07 | 0.0632 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | kinesin family 1 | 0.1258 | 1 | 1 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0023 | 0 | 0.5 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0163 | 0.1137 | 1 |
Plasmodium falciparum | kinesin-5 | 0.0163 | 0.1137 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0202 | 0.1449 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.0109 | 0.07 | 0.0632 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0202 | 0.1449 | 0.1387 |
Echinococcus granulosus | carbonic anhydrase | 0.0109 | 0.07 | 0.0632 |
Echinococcus multilocularis | carbonic anhydrase | 0.0109 | 0.07 | 0.0632 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0202 | 0.1449 | 1 |
Chlamydia trachomatis | glutamine binding protein | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | kinesin eg-5 | 0.0163 | 0.1137 | 0.0548 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0023 | 0 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.0202 | 0.1449 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0023 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.52 uM | Blockade of capsaicin-activated rat TRPV1 channel expressed in Xenopus oocytes | ChEMBL. | 17985859 |
IC50 (binding) | = 0.52 uM | Blockade of capsaicin-activated rat TRPV1 channel expressed in Xenopus oocytes | ChEMBL. | 17985859 |
IC50 (binding) | = 17 uM | Blockade of L-glutamate/glycine-activated rat NR1/NR2A NMDA receptor expressed in Xenopus oocytes | ChEMBL. | 17985859 |
IC50 (binding) | = 17 uM | Blockade of L-glutamate/glycine-activated rat NR1/NR2A NMDA receptor expressed in Xenopus oocytes | ChEMBL. | 17985859 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.