Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | growth hormone secretagogue receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | rhodopsin-like orphan GPCR | growth hormone secretagogue receptor | 289 aa | 243 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 0.0084 | 0.0533 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0008 | 0.0019 | 0.0022 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0012 | 0.0063 | 0.0044 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0008 | 0.0019 | 0.0022 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0114 | 0.1234 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0014 | 0.0084 | 0.0533 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0039 | 0.037 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0039 | 0.037 | 1 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0012 | 0.0063 | 0.0044 |
Entamoeba histolytica | kinesin, putative | 0.0114 | 0.1234 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0014 | 0.0084 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0014 | 0.0084 | 0.0533 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0042 | 0.0402 | 0.3151 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.0063 | 0.0072 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0045 | 0.0446 | 0.0513 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.0063 | 0.0072 |
Schistosoma mansoni | hypothetical protein | 0.0765 | 0.8691 | 1 |
Brugia malayi | Kinesin motor domain containing protein | 0.0114 | 0.1234 | 1 |
Schistosoma mansoni | kinesin eg-5 | 0.0114 | 0.1234 | 0.1419 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0114 | 0.1234 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0042 | 0.0402 | 0.0383 |
Giardia lamblia | Kinesin-5 | 0.0114 | 0.1234 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0042 | 0.0402 | 0.0383 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0042 | 0.0402 | 0.3151 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0008 | 0.0019 | 0.0022 |
Brugia malayi | Cytochrome P450 family protein | 0.0014 | 0.0084 | 0.0533 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0012 | 0.0063 | 0.0361 |
Plasmodium vivax | kinesin-5 | 0.0114 | 0.1234 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0045 | 0.0446 | 0.0513 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 0.0084 | 0.0533 |
Echinococcus granulosus | voltage gated potassium channel | 0.0012 | 0.0063 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0339 | 0.2632 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0038 | 0.0156 |
Echinococcus multilocularis | kinesin family 1 | 0.0879 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0063 | 0.0361 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0014 | 0.0084 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0012 | 0.0063 | 0.0044 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0008 | 0.0019 | 0.0022 |
Plasmodium falciparum | kinesin-5 | 0.0114 | 0.1234 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0014 | 0.0084 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0014 | 0.0084 | 0.5 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0008 | 0.0019 | 0.0022 |
Leishmania major | cytochrome p450-like protein | 0.0014 | 0.0084 | 0.5 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0008 | 0.0019 | 0.0022 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 12 nM | Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay | ChEMBL. | 17869100 |
EC50 (functional) | = 12 nM | Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay | ChEMBL. | 17869100 |
ED50 (functional) | = 26.4 uM/g | Agonist activity at GHS receptor in intravenously dosed anesthetized Wistar rat after 15 mins | ChEMBL. | 17869100 |
ED50 (functional) | = 26.4 uM/g | Agonist activity at GHS receptor in intravenously dosed anesthetized Wistar rat after 15 mins | ChEMBL. | 17869100 |
Ki (binding) | = 190 nM | Displacement of [125I]Ghrelin from human GHSR1a after 1 hr | ChEMBL. | 17869100 |
Ki (binding) | = 190 nM | Displacement of [125I]Ghrelin from human GHSR1a after 1 hr | ChEMBL. | 17869100 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.