Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, alpha | 451 aa | 372 aa | 25.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dual specificity | 0.009 | 0.1935 | 0.4611 |
Entamoeba histolytica | hypothetical protein | 0.009 | 0.1935 | 1 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.009 | 0.1935 | 0.5 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.009 | 0.1935 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.508 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.4197 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.009 | 0.1935 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.9533 | 0.9935 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0301 | 0.9583 | 0.9583 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.009 | 0.1935 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0301 | 0.9583 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.009 | 0.1935 | 0.1935 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.009 | 0.1935 | 0.0022 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0301 | 0.9583 | 0.9583 |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.508 | 1 |
Echinococcus multilocularis | dual specificity | 0.009 | 0.1935 | 0.3809 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0176 | 0.508 | 1 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.009 | 0.1935 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.009 | 0.1935 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.4197 | 0.8261 |
Entamoeba histolytica | protein kinase, putative | 0.009 | 0.1935 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.009 | 0.1935 | 0.3809 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.4197 | 0.8261 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.83 | Inhibition of thyroid hormone receptor alpha (unknown origin) | ChEMBL. | 17467994 |
IC50 (binding) | = 7.08 | Inhibition of human thyroid hormone receptor beta 1 | ChEMBL. | 17524652 |
IC50 (binding) | = 7.08 | Inhibition of thyroid hormone receptor beta (unknown origin) | ChEMBL. | 17467994 |
Log IC50 (binding) | = 5.83 | Inhibition of thyroid hormone receptor alpha (unknown origin) | ChEMBL. | 17467994 |
Log IC50 (binding) | = 7.08 | Inhibition of human thyroid hormone receptor beta 1 | ChEMBL. | 17524652 |
Log IC50 (binding) | = 7.08 | Inhibition of thyroid hormone receptor beta (unknown origin) | ChEMBL. | 17467994 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.